Results 21 to 30 of about 1,497 (173)

Intrauterine Transplantation of Isogenic Pancreatic Islets in Experimental Diabetic Rats.

Journal of Veterinary Medical Science, 1994
The effect of intrauterine transplantation (IU group) as a potential immunologically privileged site on the diabetic state of the recipient was compared with that of conventional intraperitoneal transplantation (IP group) using Fisher 344 rats. Islets were isolated from the pancreata of normal rats and transplanted into the uterus and peritoneal cavity
I, Sakonju, Y, Taura, M, Nakaichi, S, Nakama, S, Kagabu   +4 more
openaire   +3 more sources

Transplante isogênico de ilhotas de Langerhans no fígado de ratos: metodologia para separação e purificação das ilhotas de Langerhans Isogenic islet transplantation on the rat liver: Method for isolation and purification of the rat islets

Arquivos de Gastroenterologia, 2000
A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina mantendo os níveis glicêmicos dentro da normalidade.
Eleazar CHAIB, Apostolos PAPALOIS, Ingrid G. M. BRONS, Roy Y. CALNE   +3 more
doaj   +1 more source

Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway

Journal of Cellular and Molecular Medicine, Volume 23, Issue 8, Page 5390-5402, August 2019., 2019
Abstract Allograft interstitial fibrosis was characterized by massive extracellular matrix deposition caused by activated fibroblasts and myofibroblasts. Epithelial‐mesenchymal transition (EMT) is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis.
Jiajun Zhou, Hong Cheng, Zijie Wang, Hao Chen, Chuanjian Suo, Hengcheng Zhang, Jiayi Zhang, Yanhao Yang, Liang Geng, Ming Gu, Ruoyun Tan   +10 more
wiley   +1 more source

Induced Pluripotent Stem Cells Meet Genome Editing [PDF]

, 2018
It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments - the generation of human induced pluripotent stem cells (iPSCs) and the ...
Hockemeyer, Dirk, Jaenisch, Rudolf
core   +1 more source

Effects of Iso and Xeno Fetal Liver Fragments Transplantation on Acute and Chronic Liver Failure in Rats

Cell Transplantation, 1994
Isogeneic (rat) and xenogeneic (swine) fetal liver fragments (FLF) transplantation into the omentum was performed for d-galactosamine (d-Gal)-induced acute and carbon tetrachloride (CCI 4 )-induced chronic hepatic failure in rats. The recipients that had
M. Hagihara, T. Shimura, K. Takebe, B. Munkhbat, K. Tsuji   +4 more
doaj   +1 more source

Renal Allograft Rejection: Noninvasive Ultrasound‐ and MRI‐Based Diagnostics

Contrast Media &Molecular Imaging, Volume 2019, Issue 1, 2019., 2019
To date, allogeneic kidney transplantation remains the best available therapeutic option for patients with end‐stage renal disease regarding overall survival and quality of life. Despite the advancements in immunosuppressive drugs and protocols, episodes of acute allograft rejection, a sterile inflammatory process, continue to endanger allograft ...
Ulrich Jehn, Katharina Schuette-Nuetgen, Dominik Kentrup, Verena Hoerr, Stefan Reuter, Sarah Ohrndorf   +5 more
wiley   +1 more source

Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation

American Journal of Transplantation, Volume 16, Issue 3, Page 808-820, March 2016., 2016
Abstract Lipocalin 2 (Lcn2) is rapidly produced by damaged nephron epithelia and is one of the most promising new markers of renal injury, delayed graft function and acute allograft rejection (AR); however, the functional importance of Lcn2 in renal transplantation is largely unknown. To understand the role of Lcn2 in renal AR, kidneys from Balb/c mice
M. I. Ashraf, H. G. Schwelberger, K. A. Brendel, J. Feurle, J. Andrassy, K. Kotsch, H. Regele, J. Pratschke, H. T. Maier, F. Aigner   +9 more
wiley   +1 more source

Noradrenergic and Cholinergic Reinnervation of Islet Grafts in Diabetic Rats

Cell Transplantation, 1996
Grafted islets become denervated due to the islet transplantation procedure. The aim of the present study was 1) to examine whether islet grafts in the liver, the spleen, and under the kidney capsule in rats become reinnervated following the ...
Harmina Houwing, Roelie M. Van Asperen, Eddy A. Van Der Zee, Paul T.R. Van Suylichem, A. Beate Oestreicher, Anton B. Steffens, Jan H. Strubbe   +6 more
doaj   +1 more source

Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model

Stem Cells International, Volume 2015, Issue 1, 2015., 2015
Application of mesenchymal stromal cells (MSC) has been proposed for solid organ transplantation based on their potent immunomodulatory effects. Since side effects from the injection of large cells cannot be excluded, the hypothesis rises that extracellular vesicles (EV) may cause immunomodulatory effects comparable to MSC without additional side ...
M. Koch, A. Lemke, C. Lange, Eva Mezey
wiley   +1 more source

Two Faces of TGF‐Beta1 in Breast Cancer

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Breast cancer (BC) is potentially life‐threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF‐β1 is one of many factors that have
Joanna Magdalena Zarzynska, Arkadiusz Orzechowski   +1 more
wiley   +1 more source