Results 101 to 110 of about 17,057 (320)
A single active site in the mariner transposase cleaves DNA strands of opposite polarity [PDF]
, 2017 The RNase H structural fold defines a large family of nucleic acid metabolizing enzymes that catalyze phosphoryl transfer reactions using two divalent metal ions in the active site.
Chalmers, Ronald +1 more
core +1 more source
Structuring the bacterial genome: Y1-transposases associated with REP-BIME sequences
Nucleic Acids Research, 2011 REPs are highly repeated intergenic palindromic sequences often clustered into structures called BIMEs including two individual REPs separated by short linker of variable length. They play a variety of key roles in the cell.
B. Ton-Hoang +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu +20 more
wiley +1 more source
Genomic analysis of 48 paenibacillus larvae bacteriophages [PDF]
, 2018 Indexación: Scopus.Funding: Research at UNLV was funded by National Institute of General Medical Sciences grant GM103440 (NV INBRE), the UNLV School of Life Sciences, and the UNLV College of Sciences. E.C.-N.
Castro-Nallar, E. +7 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
Cell & Bioscience, 2011 Background Laribacter hongkongensis is associated with community-acquired gastroenteritis and traveler's diarrhea. In this study, we performed an in-depth annotation of the genes in its genome related to the various steps in the infective process, drug ...
Lau Susanna KP +7 more
doaj +1 more source
Target DNA structure plays a critical role in RAG transposition. [PDF]
PLoS Biology, 2006 Antigen receptor gene rearrangements are initiated by the RAG1/2 protein complex, which recognizes specific DNA sequences termed RSS (recombination signal sequences).
Jennifer E Posey +3 more
doaj +1 more source
Comparative pan-genome analysis of Piscirickettsia salmonis reveals genomic divergences within genogroups [PDF]
, 2017 Indexación: Scopus.Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia, a disease that seriously affects the salmonid industry. Despite efforts to genomically characterize P.
Cárcamo, J.G. +11 more
core +2 more sources
Autoregulation of phage μ transposase at the level of translation [PDF]
Nucleic Acids Research, 1988 The bacteriophage Mu A and B genes, which lie adjacent to each other and are colinear on the phage genome, encode proteins that catalyze efficient transposition of Mu DNA. We show that the molar ratio of A and B proteins is approximately 1:20 in extracts prepared after induction of cells containing a Mu lysogen or a plasmid carrying the Mu fragment ...
R L, Parsons, R, Harshey
openaire +2 more sources
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source