Results 91 to 100 of about 17,057 (320)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

DNA transposons have colonized the genome of the giant virus Pandoravirus salinus [PDF]

, 2015
BACKGROUND: Transposable elements are mobile DNA sequences that are widely distributed in prokaryotic and eukaryotic genomes, where they represent a major force in genome evolution.
Cheng Sun, Cédric Feschotte, Rachel Lockridge Mueller, Zhiqiang Wu   +3 more
core   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Transposase interaction with the β sliding clamp: Effects on insertion sequence proliferation and transposition rate [PDF]

, 2015
Insertion sequences (ISs) are ubiquitous and abundant mobile genetic elements in prokaryotic genomes. ISs often encode only one protein, the transposase, which catalyzes their transposition.
Amils, Ricardo, Díaz-Maldonado, Héctor, Gómez, Manuel J., López de Saro, Francisco J., Moreno-Paz, Mercedes, Parro, Víctor, San Martín-Úriz, Patxi   +6 more
core   +2 more sources

Structural Determinants of Sleeping Beauty Transposase Activity [PDF]

Molecular Therapy, 2016
Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected ...
Abrusán, György, Yant, Stephen R., Szilágyi, András, Marsh, Joseph A., Mátés, Lajos, Izsvák, Zsuzsanna, Barabas, Orsolya, Ivics, Zoltán   +7 more
openaire   +3 more sources

TnpPred: A Web Service for the Robust Prediction of Prokaryotic Transposases

Comparative and Functional Genomics, 2012
Transposases (Tnps) are enzymes that participate in the movement of insertion sequences (ISs) within and between genomes. Genes that encode Tnps are amongst the most abundant and widely distributed genes in nature.
Gonzalo Riadi, Cristobal Medina-Moenne, D. Holmes   +2 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Genome-wide target profiling of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy

BMC Biotechnology, 2011
Background DNA transposons have emerged as indispensible tools for manipulating vertebrate genomes with applications ranging from insertional mutagenesis and transgenesis to gene therapy.
Yu Robert K, Chung Pei-Cheng, Yang Herng-Shing, Weirauch Matthew T, Meir Yaa-Jyuhn J, Wu Sareina C-Y   +5 more
doaj   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography [PDF]

, 2007
Soil bacteria that also form mutualistic symbioses in plants encounter two major levels of selection. One occurs during adaptation to and survival in soil, and the other occurs in concert with host plant speciation and adaptation. Actinobacteria from the
Alloisio, Nicole, Bagnarol, Emilie, Bassi, Carla A., Berry, Alison M., Bickhart, Derek M., Choisne, Nathalie, Couloux, Arnaud, Cournoyer, Benoit, Cruveiller, Stephane, Daubin, Vincent, Demange, Nadia, Francino, Maria Pilar, Gogarten, Johann P., Goltsman, Eugene, Huang, Ying, Kopp, Olga R., Labarre, Laurent, Lapierre, Pascal, Normand, Philippe, Tisa, Louis S.   +19 more
core   +2 more sources