Emerging Dissemination of blaCTX‐M‐65 in Bovine E. coli in Spain Associated With IncHI2 Plasmids
The resistome in ESBL/AmpC‐producing E. coli in livestock was diverse and dominated by plasmid‐borne genes Detection of host‐independent dissemination of AMR determinants mediated by shared plasmid types First report in Spanish cattle of blaCTX‐M‐65 on IncHI2 plasmids, an under‐reported ESBL in Europe Identification of potentially zoonotic clones in ...
Medelin Ocejo +2 more
wiley +1 more source
A versatile CRISPR-associated transposases-mediated toolkit for transcriptional regulation library. [PDF]
Zhang Y +9 more
europepmc +1 more source
VDJ recombination: a transposase goes to work.
Roth, David B, Craig, Nancy L
openaire +2 more sources
The Role of N6‐Methyladenosine Modification in Health and Disease
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
Transposon-based genome editing of industrial microorganisms: advances, challenges, and prospects. [PDF]
Zhang Z +5 more
europepmc +1 more source
Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge +9 more
wiley +1 more source
Correction: Archaea express circular isoforms of IS200/IS605-associated ωRNAs. [PDF]
Picinato BA +4 more
europepmc +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Correction: Genomic islands and plasmid borne antimicrobial resistance genes drive the evolution of high-risk, ST-131 uropathogenic E. coli NS30. [PDF]
Peketi ASK, Nagaraja V, Bulagonda EP.
europepmc +1 more source

