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Geographic patterns of antibiotic resistance in the human gut microbiome: insights from metagenome-assembled genomes across four Chinese provinces. [PDF]
Front MicrobiolZhou S +7 more
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Capturing transposases for new proteins
Nature Reviews Genetics, 2021A new study by Cosby et al., investigating the role of DNA transposable elements in exon shuffling, reports that transposase capture is a recurrent process in evolution underlying the origin of new regulators of gene expression.
Linda Koch
exaly +3 more sources
DDE transposases: Structural similarity and diversity [PDF]
Advanced Drug Delivery Reviews, 2010 DNA transposons are mobile DNA elements that can move from one DNA molecule to another and thereby deliver genetic information into human chromosomes in order to confer a new function or replace a defective gene. This process requires a transposase enzyme. During transposition DD[E/D]-transposases undergo a series of conformational changes.
Irina Nesmelova, Eric P Rahrmann
exaly +3 more sources
Transposase–Transposase Interactions in MOS1 Complexes: A Biochemical Approach
Journal of Molecular Biology, 2011Transposases are proteins that have assumed the mobility of class II transposable elements. In order to map the interfaces involved in transposase-transposase interactions, we have taken advantage of 12 transposase mutants that impair mariner transposase-transposase interactions taking place during transposition.
Guillaume, Carpentier +5 more
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Integrating DNA: Transposases and Retroviral Integrases
Annual Review of Microbiology, 1999▪ Abstract Transposable elements appear quite disparate in their organization and in the types of genetic rearrangements they promote. In spite of this diversity, retroviruses and many transposons of both prokaryotes and eukaryotes show clear similarities in the chemical reactions involved in their transposition.
L, Haren, B, Ton-Hoang, M, Chandler
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2023
Tn5 Transposase is an enzyme that binds to the end of a transposon and catalyzes its movement to another part of the genome by a cut-and-paste mechanism or a "replicative transposition mechanism. Genes encoding transposases are widespreadthe most abundant in the genomes of most organisms and are the most abundant genes known.
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Tn5 Transposase is an enzyme that binds to the end of a transposon and catalyzes its movement to another part of the genome by a cut-and-paste mechanism or a "replicative transposition mechanism. Genes encoding transposases are widespreadthe most abundant in the genomes of most organisms and are the most abundant genes known.
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Evidence for “Unseen” Transposase–DNA Contacts
Journal of Molecular Biology, 2002In this study, evidence of novel, important interactions between a hyperactive Tn5 transposon recognition end sequence and hyperactive Tn5 transposase (Tnp) are presented. A hyperactive Tn5 end sequence, the mosaic end (ME), was isolated previously.
Mindy, Steiniger-White +4 more
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Transposase-driven rearrangements in human tumors
Nature Genetics, 2017A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.
Stephen C, Mack +2 more
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DNA binding domains in Tn3 transposase
Molecular and General Genetics MGG, 1993Various segments of Tn3 transposase were fused individually to beta-galactosidase, and the resulting fusion proteins were examined for their DNA binding ability by a nitrocellulose filter binding assay. Analyses of a series of the fusion proteins revealed that the N-terminal segment of the transposase (amino acid positions 1-242; the transposase gene ...
T, Maekawa +2 more
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