Results 41 to 50 of about 17,057 (320)
Nucleic Acids Research, 2017 Integrating DNA delivery systems hold promise for many applications including treatment of diseases; however, targeted integration is needed for improved safety.
Wentian Luo +5 more
semanticscholar +1 more source
Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]
, 2019 O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol +4 more
core +2 more sources
Molecular Medicine Reports, 2019 Transposases are ubiquitous mobile genetic elements responsible for genome development, driving rearrangements, such as insertions, deletions and translocations.
M. Musat +5 more
semanticscholar +1 more source
AnimalsStreptococcus suis is an important zoonotic pathogen that can cause meningitis and septicemia in swine and humans. Among numerous pathogenic serotypes, S.
Qi Sheng +3 more
doaj +1 more source
Comparative genome analysis of Wolbachia strain wAu [PDF]
, 2014 BACKGROUND: Wolbachia intracellular bacteria can manipulate the reproduction of their arthropod hosts, including inducing sterility between populations known as cytoplasmic incompatibility (CI). Certain strains have been identified that are unable to
Harris, Simon R. +3 more
core +2 more sources
Transposase-mediated gene modulation in the placenta [PDF]
Placenta, 2017 The placenta is an organ vital to fetal development as well as the maintenance of a healthy pregnancy and plays a crucial role in developmental programming of the fetus. The mechanisms that link intrauterine milieu, fetal health and disease development later in life are poorly understood. Placenta-specific gene modulation, both by generating transgenic
Marlee Elston, Johann Urschitz
openaire +2 more sources
Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.
JCI Insight, 2018 Our understanding of the molecular pathogenesis of childhood cancers has advanced substantially, but their fundamental causes remain poorly understood. Recently, multiple mechanisms of DNA damage and repair have been associated with mutations observed in
A. Henssen, A. Kentsis
semanticscholar +1 more source
, 2023 Tn5 Transposase is an enzyme that binds to the end of a transposon and catalyzes its movement to another part of the genome by a cut-and-paste mechanism or a "replicative transposition mechanism. Genes encoding transposases are widespreadthe most abundant in the genomes of most organisms and are the most abundant genes known.
openaire +1 more source
International Journal of Molecular Sciences, 2018 Rolling-circle replication (RCR) elements constitute a diverse group that includes viruses, plasmids, and transposons, present in hosts from all domains of life.
Pedro Heringer, G. Kuhn
semanticscholar +1 more source
Nature Communications, 2016 Sleeping Beauty is used as a genome engineering tool in a range of organisms. Here, the authors solve an atomic structure of Sleeping Beauty (SB) transposase and model the target DNA into the active site, elucidating details that may enable the rational ...
Franka Voigt +8 more
doaj +1 more source