Results 21 to 30 of about 10,355 (255)
Bacterial transposases and retroviral integrases [PDF]
Molecular Microbiology, 1995 SummaryTransposable genetic elements have adopted two major strategies for their displacement from one site to another within and between genomes. One involves passage through an RNA intermediate prior to synthesis of a DNA copy while the other is limited uniquely to DNA intermediates.
P, Polard, M, Chandler
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RAREFAN: A webservice to identify REPINs and RAYTs in bacterial genomes
Peer Community Journal, 2023 Compared to eukaryotes, repetitive sequences are rare in bacterial genomes and usually do not persist for long. Yet, there is at least one class of persistent prokaryotic mobile genetic elements: REPINs.
Fortmann-Grote, Carsten +2 more
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Tn5 Transposase Applied in Genomics Research [PDF]
International Journal of Molecular Sciences, 2020 The development of high-throughput sequencing (next-generation sequencing technology (NGS)) and the continuous increase in experimental throughput require the upstream sample processing steps of NGS to be as simple as possible to improve the efficiency of the entire NGS process.
Li, Niannian +5 more
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The Happy Hopping of Transposons: The Origins of V(D)J Recombination in Adaptive Immunity
Frontiers in Ecology and Evolution, 2022 Nearly 50% of the human genome is derived from transposable elements (TEs). Though dysregulated transposons are deleterious to humans and can lead to diseases, co-opted transposons play an important role in generating alternative or new DNA sequence ...
Rishi V. Shridharan +3 more
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Isolation and characterization of Tn7 transposase gain‐of‐function mutants: a model for transposase activation [PDF]
The EMBO Journal, 2000 Tn7 transposition has been hypothesized to require a heteromeric transposase formed by two Tn7-encoded proteins, TnsA and TnsB, and accessory proteins that activate the transposase when they are associated with an appropriate target DNA. This study investigates the mechanism of Tn7 transposase activation by isolation and analysis of transposase gain-of-
F, Lu, N L, Craig
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Transposon domestication versus mutualism in ciliate genome rearrangements. [PDF]
PLoS Genetics, 2013 Ciliated protists rearrange their genomes dramatically during nuclear development via chromosome fragmentation and DNA deletion to produce a trimmer and highly reorganized somatic genome.
Alexander Vogt +3 more
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Identification and characterization of domesticated bacterial transposases [PDF]
Genome Biology and Evolution, 2017 ABSTRACT Selfish genetic elements (SGEs), such as insertion sequences (ISs) and transposons are found in most genomes. Transposons are usually identifiable by their high copy number within genomes. In contrast REP associated tyrosine transposases (RAYTs), a recently described class of bacterial transposase, are ...
Bertels, Frederic +2 more
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Mutator Transposase Is Widespread in the Grasses [PDF]
Plant Physiology, 2001 Abstract Although the Mutator (Mu) system is well characterized in maize (Zea mays), very little is known about this highly mutagenic system of transposons in other grasses. Mutator is regulated by the MuDRclass of elements, which encodes two genes, one of which,mudrA, has similarity to a number of bacterial transposases.
D R, Lisch +3 more
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Microorganisms, 2019 A high level of transposon-mediated genome rearrangement is a common trait among microorganisms isolated from thermal environments, probably contributing to the extraordinary genomic plasticity and horizontal gene transfer (HGT) observed in these ...
Alba Blesa +5 more
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Subunit Interactions in the mariner Transposase [PDF]
Genetics, 1996 Abstract We have studied the Mos1 transposase encoded by the transposable element mariner. This transposase is a member of the “D,D(35)E” superfamily of proteins exhibiting the motif D,D(34)D. It is not known whether this transposase, or other eukaryote transposases manifesting the D,D(35)E domain, functions in a multimeric form ...
A R, Lohe, D T, Sullivan, D L, Hartl
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