Results 11 to 20 of about 10,355 (255)

Investigating the Trans Effects of IS<italic>1</italic> Transposases on Intragenomic DNA Movements in <italic>Escherichia coli</italic> [PDF]

Microbial Physiology
Introduction: The transposase protein, InsAB′, is the key cytoplastic determinant that catalyzes IS1 movement within a single DNA molecule or between two DNA molecules.
Jack William Ord, Zhongge Zhang, Janie Wu, Sofia Smith, Zhenhao Feng, Keisha Ancheta, Luis Fernando Garrido, Ge Yao, Sahil Gupta, Ethan T. Lee, Milton H. Saier Jr.   +10 more
doaj   +2 more sources

Multiple Buster transposons from hAT superfamily displaying transposition activities in mammal cells [PDF]

Synthetic and Systems Biotechnology
TcBuster, a member of the Buster family within the hAT superfamily, has been engineered into an effective gene transfer tool for gene therapy applications.
Zhongxia Guan, Binqing Wang, Bo Gao, Shasha Shi, Saisai Wang, Han Wu, Mohamed Diaby, Cai Chen, Xiaoyan Wang, Chengyi Song   +9 more
doaj   +2 more sources

DDE transposases: Structural similarity and diversity [PDF]

Advanced Drug Delivery Reviews, 2010
DNA transposons are mobile DNA elements that can move from one DNA molecule to another and thereby deliver genetic information into human chromosomes in order to confer a new function or replace a defective gene. This process requires a transposase enzyme. During transposition DD[E/D]-transposases undergo a series of conformational changes.
Irina Nesmelova, Perry B Hackett
exaly   +3 more sources

Archaea express circular isoforms of IS200/IS605-associated ωRNAs [PDF]

Frontiers in Microbiology
Circular RNAs (circRNAs) are RNA molecules with 5′ and 3′ ends covalently ligated. Their functions range from acting as genetic regulators to producing proteins, and they are often expressed in a tissue and condition-specific manner.
Beatriz A. Picinato, Vinícius H. Franceschini-Santos, Lívia S. Zaramela, Ricardo Z. N. Vêncio, Tie Koide   +4 more
doaj   +2 more sources

Cargo Genes of Tn7-Like Transposons Comprise an Enormous Diversity of Defense Systems, Mobile Genetic Elements, and Antibiotic Resistance Genes

mBio, 2021
Transposition is a major mechanism of horizontal gene mobility in prokaryotes. However, exploration of the genes mobilized by transposons (cargo) is hampered by the difficulty in delineating integrated transposons from their surrounding genetic context ...
Sean Benler, Guilhem Faure, Han Altae-Tran, Sergey Shmakov, Feng Zhang, Eugene Koonin   +5 more
doaj   +1 more source

PromA Plasmids Are Instrumental in the Dissemination of Linuron Catabolic Genes Between Different Genera

Frontiers in Microbiology, 2020
PromA plasmids are broad host range (BHR) plasmids, which are often cryptic and hence have an uncertain ecological role. We present three novel PromA γ plasmids which carry genes associated with degradation of the phenylurea herbicide linuron, two of ...
Johannes Werner, Eman Nour, Eman Nour, Boyke Bunk, Cathrin Spröer, Kornelia Smalla, Dirk Springael, Başak Öztürk, Başak Öztürk   +8 more
doaj   +1 more source

The unusual structure of the PiggyMac cysteine-rich domain reveals zinc finger diversity in PiggyBac-related transposases

Mobile DNA, 2021
Background Transposons are mobile genetic elements that colonize genomes and drive their plasticity in all organisms. DNA transposon-encoded transposases bind to the ends of their cognate transposons and catalyze their movement. In some cases, exaptation
Marc Guérineau, Luiza Bessa, Séverine Moriau, Ewen Lescop, François Bontems, Nathalie Mathy, Eric Guittet, Julien Bischerour, Mireille Bétermier, Nelly Morellet   +9 more
doaj   +1 more source

Nuclear importation of Mariner transposases among eukaryotes: motif requirements and homo-protein interactions. [PDF]

PLoS ONE, 2011
Mariner-like elements (MLEs) are widespread transposable elements in animal genomes. They have been divided into at least five sub-families with differing host ranges. We investigated whether the ability of transposases encoded by Mos1, Himar1 and Mcmar1
Marie-Véronique Demattei, Sabah Hedhili, Ludivine Sinzelle, Christophe Bressac, Sophie Casteret, Nathalie Moiré, Jeanne Cambefort, Xavier Thomas, Nicolas Pollet, Pascal Gantet, Yves Bigot   +10 more
doaj   +1 more source

A Review of the Functional Annotations of Important Genes in the AHPND-Causing pVA1 Plasmid

Microorganisms, 2020
Acute hepatopancreatic necrosis disease (AHPND) is a lethal shrimp disease. The pathogenic agent of this disease is a special Vibrio parahaemolyticus strain that contains a pVA1 plasmid. The protein products of two toxin genes in pVA1, pirAvp and pirBvp,
Hao-Ching Wang, Shin-Jen Lin, Arpita Mohapatra, Ramya Kumar, Han-Ching Wang   +4 more
doaj   +1 more source

Functional indications for transposase domestications – Characterization of the human piggyBac transposase derived (PGBD) activities

Gene, 2022
Transposable elements are widespread in all living organisms. In addition to self-reproduction, they are a major source of genetic variation that drives genome evolution but our knowledge of the functions of human genes derived from transposases is limited.
Kolacsek, Orsolya, Wachtl, Gerda, Fóthi, Ábel, Schamberger, Anita, Sándor, Sára, Pergel, Enikő, Varga, Nóra, Raskó, Tamás, Izsvák, Zsuzsanna, Apáti, Ágota, Orbán, Tamás I.   +10 more
openaire   +3 more sources