The repetitive genome of the Ixodes ricinus tick reveals transposable elements have driven genome evolution in ticks. [PDF]
Ronai I +9 more
europepmc +1 more source
Rapid reconstruction of multidrug‐resistant bacterial genomes using CycloneSEQ nanopore sequencing
Multidrug‐resistant (MDR) bacteria commonly harbor highly complex genomes enriched with mobile elements and resistance islands, which are challenging to resolve using short‐read sequencing. Here, we evaluated CycloneSEQ, a newly developed Chinese nanopore sequencing platform, for MDR genome reconstruction.
Kai Peng +9 more
wiley +1 more source
The telomere-to-telomere haplotype genome provides in-depth insights into the molecular mechanisms of the anthocyanin deficiency phenotype in Prunus mume. [PDF]
Zhou P +13 more
europepmc +1 more source
RNA‐Based Therapies for Inherited Metabolic Disorders
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri +5 more
wiley +1 more source
Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation. [PDF]
Rosspopoff O, Trono D, Feschotte C.
europepmc +1 more source
Bacteriophage Therapy: Current Strategies and Future Perspectives
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou +7 more
wiley +1 more source
Advancements in genomic crop techniques and considerations for regulation and food safety. [PDF]
Spaans GW +3 more
europepmc +1 more source
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
Antibiotic Resistance to Critically Important Antimicrobials and Virulence Genes in <i>Enterococcus faecalis</i> Strains Isolated from Eurasian Griffon Vultures (<i>Gyps fulvus</i>) and Their Association with Mobile Genetic Elements. [PDF]
Vela AI +8 more
europepmc +1 more source
Regulation of the amh gene promoter activity by SF-1 in sex-reversing Cheilinus undulatus and its adaptive evolution. [PDF]
Bu S +6 more
europepmc +1 more source

