Results 101 to 110 of about 1,229,293 (285)

From microbleeds to axonal damage: current evidence and future directions

Frontiers in Radiology
Traumatic brain injury (TBI) represents a major public health challenge worldwide. Traumatic axonal injury (TAI) is a key determinant of outcome yet remains difficult to assess directly in vivo in routine clinical practice and is therefore typically ...
Dávid Bognár, Dávid Bognár, Dávid Bognár, Zalán Petneházy, Zalán Petneházy, Zalán Petneházy, Péter Laár, Péter Laár, Péter Laár, Petra Bondor, Petra Bondor, Tamás Dóczi, Tamás Dóczi, Tamás Dóczi, Bálint Környei, Bálint Környei, Bálint Környei, Arnold Tóth, Arnold Tóth, Arnold Tóth   +19 more
doaj   +1 more source

Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury

Molecular Neurodegeneration, 2017
Background Optic nerve injury is an important pathological component in neurodegenerative diseases such as traumatic optic neuropathies and glaucoma. The molecular signaling pathway(s) critical for retinal ganglion cell (RGC) death after axonal insult ...
Stephanie B. Syc-Mazurek, Kimberly A. Fernandes, Michael P. Wilson, Peter Shrager, Richard T. Libby   +4 more
doaj   +1 more source

The impact of intimacy and disability on the perception toward rehabilitation processes of a person with traumatic injury [PDF]

, 2003
Plan BThe purpose of this descriptive research study was to investigate any possible interactions between the person with a traumatic injury and their perceptions of rehabilitation processes dependent on their spousal/domestic partner relationship status
Desler, Sandra
core  

Developing Core Sets for Persons With Traumatic Brain Injury Based on the International Classification of Functioning, Disability, and Health [PDF]

, 2009
The authors outline the process for developing the International Classification of Functioning, Disability, and Health (ICF) Core Sets for traumatic brain injury (TBI).
Stucki, Gerold, Barnes, Michael, Tate, Robyn, Bernabeu, Montserrat, Lopez, Raquel, Kostanjsek, Nenad, Cieza, Alarcos, Whyte, John, Zasler, Nathan, Ward, Anthony, Laxe, Sara, Reed, Geoffrey   +11 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

NSUN6 promotes neuronal axon regeneration after traumatic brain injury by enhancing HMGB1 expression via m5C modification

Brain Research Bulletin
Traumatic brain injury (TBI) often results in neurofunctional impairments that can be mitigated by promoting axonal regeneration. NOP2/Sun RNA methyltransferase 6 (NSUN6), a 5-methylcytosine (m5C) methyltransferase, has been implicated in TBI recovery ...
Lei Wang, Quanming Zhou, Jianning Chen, Jianhua Song, Weipeng Hu   +4 more
doaj   +1 more source

Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy. [PDF]

J Neurotrauma, 2023
Alexandris AS, Lee Y, Lehar M, Alam Z, McKenney J, Perdomo D, Ryu J, Welsbie D, Zack DJ, Koliatsos VE.   +9 more
europepmc   +1 more source

Is diffuse axonal injury on susceptibility weighted imaging a biomarker for executive functioning in adolescents with traumatic brain injury?

, 2019
Is diffuse axonal injury on susceptibility weighted imaging a biomarker for executive functioning in adolescents with traumatic brain ...
Ellen Deschepper (130165), Karel Deblaere (3079569), Eva Genbrugge (15806708), Catharine Vander Linden (7257956), Helena Verhalst (15806705), Karen Caeyenberghs (13078329), Guy Vingerhoets (439767)   +6 more
core  

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source