Results 71 to 80 of about 1,229,293 (285)

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Longitudinal changes of structural connectivity in traumatic axonal injury [PDF]

Neurology, 2011
To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome.The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects.
J Y, Wang, K, Bakhadirov, H, Abdi, M D, Devous, C D, Marquez de la Plata, C, Moore, C J, Madden, R, Diaz-Arrastia   +7 more
openaire   +2 more sources

Return to driving after traumatic brain injury : a British perspective [PDF]

, 2005
Primary Objective: to identify current legal situation, and professional practice in assisting persons with traumatic brain injury (TBI) to return to safe driving after injury. Methods and Procedures A brief review of relevant literature, a description
Brooks, N., Hawley, Carol
core   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. [PDF]

, 2008
BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance.
Maas, Andrew I R, McHugh, Gillian S., Steyerberg, Ewout W, Lu Juan, Butcher, I. (Isabella), Ewout W Steyerberg, Butcher, Isabella, Perel, P. (Pablo), Murray, G.D. (Gordon), Marmatou, Anthony, Murray Gordon D, Steyerberg Ewout W, McHugh, Gillian, Habbema J. Dik F, Roberts, I. (Ian), Roberts, Ian, Maas, A.I.R. (Andrew), Maas, Andrew I. R., McHugh, G.S. (Gillian), Steyerberg, E.W. (Ewout), Marmarou, A. (Anthony), Lu, Juan, Habbema, J Dik F, Mushkudiani, N. (Nino), Marmarou Anthony, Lu, J. (Juan), Juan Lu, Mushkudiani, Nino, Gillian S McHugh, Maas, Andrew IR, Andrew I R Maas, Isabella Butcher, Roberts Ian, Steyerberg, Ewout W., J Dik F Habbema, McHugh, Gillian S, Nino Mushkudiani, Anthony Marmarou, Butcher Isabella, Gordon D Murray, Habbema, J. D. F., Perel Pablo, Perel, Pablo, Murray, Gordon D, McHugh Gillian S, Ian Roberts, Mushkudiani Nino, Murray, Gordon D., Habbema, J.D.F. (Dik), Maas Andrew I. R, Pablo Perel, Marmarou, Anthony, Perel, P, Steyerberg, Ewout E., Maas, Andrew I.R., et al., Habbema, Dik, Butcher, I, McHugh, GS, Steyerberg, Ewout, Marmarou, A, Mushkudiani, N (Nino), Lu, J, Maas, AIR (Arne), Murray, GD, Roberts, I   +65 more
core   +2 more sources

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Investigating severe pediatric traumatic brain injury in South Africa : a demographic profile of admissions, brain oxygenation and neuropsychological outcomes and an attention-training intervention [PDF]

, 2013
Includes bibliographical references.The aim of this dissertation was to investigate severe pediatric traumatic brain injury (pTBI) in South Africa. To that end, I conducted three studies, each examining a different aspect of severe pTBI. Study 1 presents
Schrieff, Leigh
core   +1 more source

Characterizing brain structures and remodeling after TBI based on information content, diffusion entropy. [PDF]

PLoS ONE, 2013
To overcome the limitations of conventional diffusion tensor magnetic resonance imaging resulting from the assumption of a Gaussian diffusion model for characterizing voxels containing multiple axonal orientations, Shannon's entropy was employed to ...
Niloufar Fozouni, Michael Chopp, Siamak P Nejad-Davarani, Zheng Gang Zhang, Norman L Lehman, Steven Gu, Yuji Ueno, Mei Lu, Guangliang Ding, Lian Li, Jiani Hu, Hassan Bagher-Ebadian, David Hearshen, Quan Jiang   +13 more
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Computerised tomography indices of raised intracranial pressure and traumatic brain injury severity in a New Zealand sample [PDF]

, 2012
After traumatic brain injury (TBI) complex cellular and biochemical processes occur¹ including changes in blood flow and oxygenation of the brain; cerebral swelling; and raised intracranial pressure (ICP).² This can dramatically worsen the damage³ and ...
Feigin, Valery L., Theadom, Alice, Starkey, Nicola J., Barker-Collo, Suzanne, Kahan, Michael   +4 more
core