Results 51 to 60 of about 439,865 (314)
TreeCluster: Clustering biological sequences using phylogenetic trees.
PLoS ONE, 2019 Clustering homologous sequences based on their similarity is a problem that appears in many bioinformatics applications. The fact that sequences cluster is ultimately the result of their phylogenetic relationships.
Metin Balaban +4 more
doaj +1 more source
Structural Analysis of Polarizing Indels Argues the Root of the Tree of Life is Near the Chloroflexi
, 2009 Determining which branches of the tree of life have derived features narrows down the possible location of the root. Currently the polarization of indels done by Lake _et al_.^1-5^ and the polarizing transitions of Cavalier-Smith^6^ arrive at ...
Philip E. Bourne, Ruben E. Valas
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Vessel tree tracking in angiographic sequences [PDF]
Journal of Medical Imaging, 2017 We present a method to track vessels in angiography [contrast filled vessels in two-dimensional (2-D) x-ray fluoroscopy]. Finding correspondence of a vessel tree from consecutive angiogram frames provides significant value in computer-aided clinical applications such as fast vessel tree segmentation, three-dimensional (3-D) vessel topology ...
Dong, Zhang +4 more
openaire +2 more sources
Tree-Ring Dating of the Karr-Koussevitzky Double Bass: A Case Study in Dendromusicology
, 2005 Sergei Koussevitzky was one of the world’s premier conductors and virtuoso bass players whose favorite instrument was an unusually-shaped bass reportedly made in 1611 by the Amati brothers, Antonio and Girolamo.
Henri D. Grissino-Mayer +5 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
On Collatz' Words, Sequences and Trees
J. Integer Seq., 2014 Motivated by a recent work of Trümper we consider the general Collatz word (up-down pattern) and the sequences following this pattern. The recurrences for the first and last sequence entries are given, obtained from repeated application of the general solution of a binary linear inhomogeneous Diophantine equation. These recurrences are then solved. The
openaire +4 more sources
Simple and flexible detection of contiguous repeats using a suffix tree
, 2002 Stoye J, Gusfield D. Simple and flexible detection of contiguous repeats using a suffix tree. Theoretical Computer Science. 2002;270(1-2):843-856.We study the problem of detecting all occurrences of (primitive) tandem repeats and tandem arrays in a ...
Jens Stoye +4 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source