Results 111 to 120 of about 78,878 (198)

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Seminal fluid and cytokine control of regulatory T-cells in murine pregnancy. [PDF]

, 2010
For successful pregnancy, the maternal immune system must tolerate the presence of a fetus that expresses alloantigens. The appropriate and timely acquisition of this state of tolerance is critical and emerging evidence suggests that it needs to be ...
Guerin, Leigh R.
core   +1 more source

Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma

Advanced Science, EarlyView.
This study explores the use of ultrasound contrast agents loaded with Stimulator of Interferon Genes (STING) agonists as an approach to activate the body's immune system against cancer. Termed Microbubble‐assisted UltraSound‐guided Immunotherapy of Cancer (MUSIC), this strategy effectively inhibits tumor growth and improves survival in mouse models of ...
Sina Khorsandi, Kristin Huntoon, Yifan Wang, Adam Woodward, Abin Antony, Connor Endsley, Nazia Hafeez, Jared L. Edwards, Nicole McCuen, Prasanna G. Alluri, Betty Y.S. Kim, Wen Jiang, Jacques Lux   +12 more
wiley   +1 more source

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen, Qiyan Guo, Hong Li, Xue Chi, Xiang Ma, Yanqiong Tang, Quanfeng Liang, Zhu Liu, Yong Liu, Juanjuan Li   +9 more
wiley   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

Advanced Science, EarlyView.
This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei   +11 more
wiley   +1 more source

Genetically Engineered IL12/CSF1R‐Macrophage Membrane‐Liposome Hybrid Nanovesicles for NIR‐II Fluorescence Imaging‐Guided and Membrane‐Targeted Mild Photothermal‐Immunotherapy of Glioblastoma

Advanced Science, EarlyView.
A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen, Yue Liu, Haiyan Huang, Menglong Li, Hui Xie, Shubham Roy, Jingsi Gu, Jian Jin, Kai Deng, Lixin Du, Bing Guo   +10 more
wiley   +1 more source

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis

Advanced Science, EarlyView.
The study develops engineered exosomes (EmDEX@GA) for locoregional immunomodulation of tumor‐draining lymph node (TDLN). EmDEX@GA can actively target to TDLN and remodel its immunosuppressive microenvironment through the synergistic effects of PD‐1/PD‐L1 blockade and STING pathway activation, subsequently enhance anti‐tumor immunity and suppress tumor ...
Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren   +12 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source