Results 111 to 120 of about 275,584 (397)

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. [PDF]

, 2019
CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties.
Cho, Sunglim, Dong, Yi, Feng, Gen-Sheng, Fu, Wenxian, Jepsen, Kristen, Liang, Yan, Lu, Li-Fan, Wan, Shuo, Wang, Ke, Xu, Wanqing, Xue, Hai-Hui, Yang, Bi-Huei, Yuan, Xiaomei   +12 more
core   +1 more source

Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression [PDF]

, 2015
The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i).
Cahn, Pedro, Falivene, Juliana, Figueroa, María Inés, Gherardi, Maria Magdalena, Ghiglione, Yanina Alexandra, Giavedoni, Luis D., Holgado, María Pía, Laufer, Natalia Lorna, Maeto, Cynthia Alejandra, Ruiz, Maria Julia, Salomon, Horacio Eduardo, Socías, María Eugenia, Sued, Omar Gustavo, Turk, Gabriela Julia Ana   +13 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

Viruses, 2019
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause severe reproductive and respiratory pathologies resulting in immense monetary and welfare costs for the swine industry.
Andrew R. Kick, Amanda F. Amaral, Lizette M. Cortes, Jonathan E. Fogle, Elisa Crisci, Glen W. Almond, Tobias Käser   +6 more
doaj   +1 more source

Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes in mice [PDF]

, 2023
Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levings   +14 more
openalex   +1 more source

The correlation between the Th17/Treg cell balance and bone health

Immunity & Ageing, 2020
With the ageing of the world population, osteoporosis has become a problem affecting quality of life. According to the traditional view, the causes of osteoporosis mainly include endocrine disorders, metabolic disorders and mechanical factors.
Lei Zhu, F. Hua, Wenge Ding, Kai Ding, Yige Zhang, Chenyang Xu   +5 more
semanticscholar   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

The immunomodulation role of Th17 and Treg in renal transplantation [PDF]

, 2023
Dan-Lei Huang, Yi-Ran He, Yujing Liu, Hongyu He, Zhun-Yong Gu, Yimei Liu, Wenjun Liu, Zhe Luo, Min‐Jie Ju   +8 more
openalex   +1 more source

Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4

Journal for ImmunoTherapy of Cancer, 2020
Background Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers.
Lisa A. Marshall, Sachie Marubayashi, Aparna Jorapur, S. Jacobson, M. Zibinsky, Omar Robles, Dennis X. Hu, J. J. Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, A. Wadsworth, D. Chian, D. Wustrow, P. Kassner, G. Cutler, B. Wong, D. Brockstedt, O. Talay   +18 more
semanticscholar   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source