Results 91 to 100 of about 156,448 (312)

Kinetics of expression in the tissues after transfer of Treg and CCR2-Treg cells

, 2011
Copyright information:Taken from "Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4CD25regulatory T cells in MRL/lpr mice"http://arthritis-research.com/content/9/1/R15Arthritis Research & Therapy 2007;9(1):R15-R15.Published ...
Masaki Yasukawa (28387), Atsushi Inoue (28383), Masatake Muraoka (28384), Tatsuhiko Miyazaki (28386), Hitoshi Hasegawa (28382), Jun Yamanouchi (28385)   +5 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Treg/IL-17 Ratio and Treg Differentiation in Patients with COPD

PLoS ONE, 2014
Chronic obstructive pulmonary disease (COPD) is characterized by chronic pulmonary and systematic inflammation. An abnormal adaptive immune response leads to an imbalance between pro- and anti-inflammatory processes. T-helper (Th), T-cytotoxic (Tc) and T-regulatory (Treg) cells may play important roles in immune and inflammatory responses.
Yang Jin, Yong Wan, Gang Chen, Long Chen, Ming-Qiang Zhang, Li Deng, Jian-Chu Zhang, Xian-Zhi Xiong, Jian-Bao Xin   +8 more
openaire   +4 more sources

Modulation of host immunity by Treg-inducing probiotics　

, 2019
Intestinal microbiota plays a critical role in the modulation of human health. Dysregulation of the commensal flora is closely linked to functional changes of the immune system and subsequently contributes to development of immune disorders.
IM, SIN HYEOG
core  

Treg cell analysis.

, 2013
PBMC were stained for the cell surface markers CD4, CD25, and CD127, followed by intracellular staining for Foxp3. (A) Lymphocytes were firstly gated on CD4 expression. All gated CD4 cells expressed CD3 (data not shown).
Kim A. Piera (35531), Magdalena Plebanski (21001), Ric N. Price (35538), Tonia Woodberry (349326), Nicholas M. Anstey (35535), Gabriela Minigo (373171), Christian R. Engwerda (42442), Ervi Salwati (373174), Enny Kenangalem (35528), Emiliana Tjitra (35536)   +9 more
core   +1 more source

Mild hypothermia provides Treg stability [PDF]

, 2017
Regulatory T cells (Tregs) play crucial role in maintenance of peripheral tolerance. Recent clinical trials confirmed safety and efficacy of Treg treatment of deleterious immune responses.
Natalia Marek-Trzonkowska, Natalia Filipowicz, Piotr Trzonkowski, Sawitzki, Birgit, Piekarska, Karolina, Piotrowski, Arkadiusz, Magdalena Gucwa, Gucwa, Magdalena, Filipowicz, Natalia, Siebert, Janusz, Katrin Vogt, Marek-Trzonkowska, Natalia, Trzonkowski, Piotr, Arkadiusz Piotrowski, Janusz Siebert, Birgit Sawitzki, Vogt, Katrin, Karolina Piekarska   +17 more
core   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Tregitopes switch on Tregs

Blood, 2008
In this issue of Blood, De Groot and colleagues report the identification and functional characterization of Tregitopes, which are Treg-activating regions in the Fc portion of the IgG molecule. This important finding has the potential to bring understanding about a number of phenomena related to Ig, including tolerance to Ab variable regions, the ...
openaire   +3 more sources

Modulation of host immunity by Treg-inducing Bacteria

, 2019
Intestinal microbiota plays a critical role in the modulation of human health. Dysregulation of the commensal flora is closely linked to functional changes of the immune system and subsequently contributes to development of immune disorders.
IM, SIN HYEOG
core  

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source