Results 71 to 80 of about 167,295 (312)

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

OncoImmunology, 2019
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of in vivo vaccination.
Hester J. Scheffer, Anita G.M. Stam, Bart Geboers, Laurien G.P.H. Vroomen, Alette Ruarus, Beaunelle de Bruijn, M. Petrousjka van den Tol, Geert Kazemier, Martijn R. Meijerink, Tanja D. de Gruijl   +9 more
doaj   +1 more source

Informative value of laboratory markers in assessing the stage of liver fibrosis in children with type 1 autoimmune hepatitis

Аллергология и Иммунология в Педиатрии, 2023
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O. V. Kurbatova, G. B. Movsisyan, S. V. Petrichuk, D. V. Parakhina, D. S. Demyanov, D. G. Kuptsova, T. V. Radygina, E. L. Semikina, A. S. Potapov, E. V. Freidlin   +9 more
doaj   +1 more source

Phenotypic Analysis of CD4+ Treg, CD8+ Treg, and Breg Cells in Adult Common Variable Immunodeficiency Patients

, 2019
IntroductionRegulatory lymphocytes (CD4+ T regulatory cells [Treg], CD8+ Treg, and B regulatory cells [Breg]) play a critical role in immune homeostasis and tolerance. Common variable immunodeficiency (CVID) is associated with increased susceptibility to
Yesillik, Sait, Gollapudi, Sastry V, Gupta, Sudhir, Agrawal, Sudhanshu   +3 more
core   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

In vitro effects of paleobacteria exometabolites from permafrost soils on development of immune response

Медицинская иммунология
We have tested the effects of metabolites from paleobacteria Bacillus cereus, strain 875 TS, from Pleistocene-Holocene permafrost rocks aiming to assess the mechanisms and features of in vitro immune response in the culture of human peripheral blood ...
S. A. Pwetrov, L. F. Kalyonova, Yu. G. Sukhovey, E. G. Kostolomova, A. S. Bazhin, M. V. Narushko   +5 more
doaj   +1 more source

The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story

Microorganisms, 2019
The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota.
Hongyu Cheng, Xiong Guan, Dekun Chen, Wentao Ma   +3 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Identification of a highly suppressive Treg subset associated with immunotherapy response

, 2018
Melanoma often exploits Treg to avoid immune attack. Treg is a heterogeneous population with respect to immunosuppressive capability. Lymphocytes are particularly rich in FKBP51 (encoded by FKBP5 gene), known as the receptor for FK506.
Tufano M., Procaccini C., Novizio N, Giunta E. F., Vincenza Vigorito, Vigorito V., Nunzia Novizio, Vigorito V, Argenziano G, Matarese G., De Falco V, Rea A., Teresa Troiani, Faicchia D, Romano Simona, Argenziano G., Matarese G, Romano MF, Novizio N., Giuseppe Matarrese, Troiani T, D’Arrigo P., D'Arrigo P, Maria F. Romano, Romano MF., Fortunato Ciardiello, Giunta EF, Simona Romano, Procaccini C, Claudio Procaccini, Deriggio Faicchia, Faicchia D., D’Arrigo P, Troiani T., Paolo D'Arrigo, Ciardiello F, Giuseppe Argenziano, Martina Tufano, Anna Rea, Emilio F. Giunta, Rea A, Tufano M, Romano M. F.   +42 more
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source