Results 51 to 60 of about 174,092 (264)

Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target

Human Vaccines & Immunotherapeutics, 2019
Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri, Maryam Naseroleslami, Jamshid Hadjati   +2 more
doaj   +1 more source

NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT

Педиатрическая фармакология, 2013
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva, N. Z. Zokirov, V. V. Troshina, L. S. Namazova-Baranova, S. Y. Tarakanova   +4 more
doaj   +1 more source

Helios expression in viable Treg.

, 2013
A, Dot plots of control and mafosfamide (2 µg/ml, 48 h) treated Treg. The living fraction was gated (P1) and Helios+ cells were marked green in this fraction (designed as P2).
Huong Becker (501247), Stefaan van Gool (501248), Nicole Bacher (347165), Daniel Heylmann (317533), Kerstin Steinbrink (347167), Bernd Kaina (22761), Martina Bauer (264267)   +6 more
core   +1 more source

Novel Foxo1-dependent transcriptional programs control Treg cell function [PDF]

, 2012
Regulatory T (Treg) cells, characterized by expression of the transcription factor forkhead box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune responses1, 2, 3, 4.
Alexander Y. Rudensky, Kim, Myoungjoo V., Dies Meijer, Ouyang, WM, Peng, M, Yin, N, Ouyang, W., Will Liao, Mo, Yifan, Peng, Min, Chan, P., Ming O. Li, Huse, M., Zhao, KJ, Ouyang, Weiming, Yin, N., Michael Q. Zhang, Chan, Pamela, Kim, M. V., Ma, Q., Liao, Will, Myoungjoo V. Kim, Meijer, Dies, Luo, Chong T., Zhang, Michael Q., Peng, M., Mo, Y., Huse, Morgan, Li, MO, Qian Ma, Ma, Q, Atwal, Gurinder, Li, Ming O., Huse, M, Yifan Mo, Keji Zhao, Mo, YF, Zhao, K., Atwal, G, Rudensky, AY, Zhang, MQ, Yin, Na, Rudensky, A. Y., Li, M. O., Liao, W, Zhao, Keji, Chan, P, Chong T. Luo, Gurinder Atwal, Morgan Huse, Na Yin, Atwal, G., Luo, C. T., Liao, W., Meijer, Dies; id_orcid, Ma, Qian, Kim, MV, Meijer, D., Weiming Ouyang, Min Peng, Luo, CT, Pamela Chan, Rudensky, Alexander Y., Zhang, M. Q.   +63 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity

Immunological Medicine, 2021
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and ...
Agustinus Darmadi Hariyanto, Tiara Bunga Mayang Permata, Soehartati Argadikoesoema Gondhowiardjo   +2 more
doaj   +1 more source

MiR-206 regulates the Th17/Treg ratio during osteoarthritis

, 2021
Background The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).
Wei Xie, Jun Rao, Weijun Wang, Hao Li, Zhiwen Zhang, Qilin Lu, Chengjian He, Xiguang Ye, Aofei Yang   +8 more
core   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

CLEC5a-directed bispecific antibody for effective cellular phagocytosis

mAbs, 2022
While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB).
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng, Juan Zhang, Yongmei Chen, Haochu Huang, Wyne P. Lee, Yan Wu, Minhong Yan   +11 more
doaj   +1 more source

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

OncoImmunology, 2019
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of in vivo vaccination.
Hester J. Scheffer, Anita G.M. Stam, Bart Geboers, Laurien G.P.H. Vroomen, Alette Ruarus, Beaunelle de Bruijn, M. Petrousjka van den Tol, Geert Kazemier, Martijn R. Meijerink, Tanja D. de Gruijl   +9 more
doaj   +1 more source