Results 41 to 50 of about 167,295 (312)

Treg-mediated regulation of PD-1/PD-L1 expression on CD8 T cells from HIV+ patients is clonally-specific.

, 2016
Pooled data on the levels of PD-1 and PD-L1 expression on CEF-specific (A) and Gag-specific (B) CD8 T cell effectors stimulated overnight in the presence (black) or in the absence (white) of Treg. (* P
Christine Lacabaratz (567696), Yves Lévy (3173226), Maria Nikolova (214639), Maria Muhtarova (214675), Daniela Achkova (3338154), Aurélie Wiedemann (3338157)   +5 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Features of peripheral blood Treg and Th17 subsets during physiological pregnancy [PDF]

Exploration of Immunology
Aim: Regulatory T (Treg) cells and interleukin-17-producing T helper (Th17) cells play a critical role in successful pregnancy. Treg and Th17 cells differentiate predominantly in the thymus.
Olga Gorbunova, Ekaterina Orlova, Olga Loginova, Sergey Shirshev   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer

Frontiers in Immunology, 2018
Background: Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could be influenced or predicted by immune events that manifest locally, but can be ...
Gemma A. Foulds, Jayakumar Vadakekolathu, Tarek M. A. Abdel-Fatah, Divya Nagarajan, Stephen Reeder, Catherine Johnson, Simon Hood, Paul M. Moseley, Stephen Y. T. Chan, A. Graham Pockley, Sergio Rutella, Stephanie E. B. McArdle   +11 more
doaj   +1 more source

IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses

Frontiers in Immunology, 2020
Despite the great impact on long-term survival of some cancer patients, the immune checkpoint blockade (ICB) therapy is limited by its low response rates for most cancers.
Qiuxia Qu, Zhiwei Zhai, Jieni Xu, Song Li, Cheng Chen, Binfeng Lu, Binfeng Lu   +6 more
doaj   +1 more source

Regulation of T cell differentiation by the AP-1 transcription factor JunB

Immunological Medicine, 2021
JunB, a component of the activator protein-1 (AP-1) transcription factor, is known to exhibit an important role in bone formation and bone marrow cell proliferation. During T helper type 2 (Th2) cell differentiation, JunB contributes to the regulation of
Takaharu Katagiri, Hideto Kameda, Hiroyasu Nakano, Soh Yamazaki   +3 more
doaj   +1 more source

Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice

Frontiers in Pharmacology, 2022
Although the antitumor efficacy of immune checkpoint blockade (ICB) has been proved in colorectal cancer (CRC), the results are unsatisfactory, presumably owing to the presence of tryptophan metabolism enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and ...
Rongjie Zhang, Yuanfeiyi Wang, Dan Liu, Qing Luo, Peixin Du, Haiyan Zhang, Haiyan Zhang, Wenshuang Wu, Wenshuang Wu   +8 more
doaj   +1 more source

Treg cells to the rescue [PDF]

Arthritis & Rheumatism, 2012
In this issue of Arthritis & Rheumatism, Kong and colleagues report that collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), can be effectively treated by systemic injection of Treg cells (1). These results raise several questions: Are there defects in Treg cell numbers or function in RA?
openaire   +3 more sources