Results 41 to 50 of about 174,092 (264)
Frontiers in Pharmacology, 2022 Although the antitumor efficacy of immune checkpoint blockade (ICB) has been proved in colorectal cancer (CRC), the results are unsatisfactory, presumably owing to the presence of tryptophan metabolism enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and ...
Rongjie Zhang +8 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]
, 2011 In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core +1 more source
Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis
Frontiers in Pharmacology, 2021 It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration ...
Pan Lin Xin +4 more
doaj +1 more source
Schematic representation of GXMGal effects on Treg (A) and on Treg/Th17 balance (B).
, 2014 Schematic representation of GXMGal effects on Treg (A) and on Treg/Th17 balance (B).
Arturo Casadevall (21382) +9 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Frontiers in Immunology, 2019 Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong correlation between induction of
Roland W. Herzog +4 more
doaj +1 more source
, 2019 IntroductionRegulatory lymphocytes (CD4+ T regulatory cells [Treg], CD8+ Treg, and B regulatory cells [Breg]) play a critical role in immune homeostasis and tolerance. Common variable immunodeficiency (CVID) is associated with increased susceptibility to
Yesillik, Sait +3 more
core +1 more source
Die Rolle donorstämmiger Treg-Zellen im murinen Modell der autologen und allogenen Knochenmarktransplantation [PDF]
, 2022 Die allogene Stammzelltransplantation (HSZT) stellt ein etabliertes Therapieverfahren zur Behandlung maligner und nicht-maligner Erkrankungen des hämatopoetischen Systems dar.
Benkowitsch, Nikolai
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source