Results 21 to 30 of about 156,448 (312)

Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice

Frontiers in Immunology, 2019
Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong correlation between induction of
Roland W. Herzog, Veronica Kuteyeva, Rania Saboungi, Cox Terhorst, Moanaro Biswas   +4 more
doaj   +1 more source

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

Pharmaceutical Biology, 2022
Context Many natural extracts have been shown to minimize the toxicity of doxorubicin (Dox). Low piperine Piper nigrum L. (Piperaceae) extract (PFPE) is a natural extract containing many types of antioxidants that may reduce Dox toxicities.
Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist   +7 more
doaj   +1 more source

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

, 2021
International audienceCD4+Foxp3+ regulatory T (Treg) cells are central modulators of autoimmune diseases. However, the timing and location of Treg cell-mediated suppression of tissue-specific autoimmunity remain undefined.
Kassem, Sahar, Lombardi, Yannis, Martin, Gaëlle, H, Grinberg-Bleyer, Yenkel, Ronin, Emilie, Pouchy, Charlotte, Sleurs, David, Lucas, Bruno, Grégoire, Sylvie, Wajant, Harald, Marodon, Gilles, Martin, Gaëlle,, Chanson, Noémie, Casrouge, Armanda, Lalle, Guilhem, Hilaire, Morgane, Salomon, Benoît, L, Auffray, Cédric, Khosravi, Maryam, Salomon, Benoît,   +19 more
core   +1 more source

Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target

Human Vaccines & Immunotherapeutics, 2019
Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri, Maryam Naseroleslami, Jamshid Hadjati   +2 more
doaj   +1 more source

NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT

Педиатрическая фармакология, 2013
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva, N. Z. Zokirov, V. V. Troshina, L. S. Namazova-Baranova, S. Y. Tarakanova   +4 more
doaj   +1 more source

CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis

Autoimmunity, 2023
Sepsis-induced acute respiratory distress syndrome (ARDS) remains a major complication of death from bacterial infection. Regulatory T cells (Tregs) are important regulators in addressing lung injury.
Jian Zhong, Wei Zhang, Leiyun Zhang, Jieying Li, Lingkai Kang, Xiaoyue Li   +5 more
doaj   +1 more source

Rapamycin relieves lupus nephritis by regulating TIM-3 and CD4+CD25+Foxp3+ Treg cells in an MRL/lpr mouse model

, 2022
Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus (SLE) and is an important driver of morbidity and mortality in SLE. Treg cells and TIM-3 play an important role in the pathogenesis of LN.
Xiao-shuang Zhou, Yan-fang Gao, Xiu-zhao Fan, Rong-shan Li   +3 more
core   +1 more source

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

OncoImmunology, 2019
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of in vivo vaccination.
Hester J. Scheffer, Anita G.M. Stam, Bart Geboers, Laurien G.P.H. Vroomen, Alette Ruarus, Beaunelle de Bruijn, M. Petrousjka van den Tol, Geert Kazemier, Martijn R. Meijerink, Tanja D. de Gruijl   +9 more
doaj   +1 more source

Upregulation of Cytokines and Differentiation of Th17 and Treg by Dendritic Cells: Central Role of Prostaglandin E2 Induced by Mycobacterium bovis

Microorganisms, 2020
Mycobacterium bovis (M. bovis) is a zoonotic pathogen that causes bovine and human tuberculosis. Dendritic cells play a critical role in initiating and regulating immune responses by promoting antigen-specific T-cell activation.
Han Liu, Xuekai Xiong, Wenjun Zhai, Tingting Zhu, Xiaojie Zhu, Yifan Zhu, Yongchong Peng, Yongliang Zhang, Jieru Wang, Huanchun Chen, Yingyu Chen, Aizhen Guo   +11 more
doaj   +1 more source

Treg

, 2009
The potential use of CD4(+)Foxp3(+) Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to reverse established disease.
Stephens LA, Anderton SM, Stephen M. Anderton, Katy H. Malpass, Malpass KH, Leigh A. Stephens   +5 more
core   +2 more sources