Results 11 to 20 of about 130,508 (261)
Annual Review of Immunology, 2016 The immune system is responsible for defending an organism against the myriad of microbial invaders it constantly confronts. It has become increasingly clear that the immune system has a second major function: the maintenance of organismal homeostasis. Foxp3+CD4+regulatory T cells (Tregs) are important contributors to both of these critical activities,
Marisella, Panduro +2 more
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ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases [PDF]
Frontiers in Immunology, 2020 Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells. The ICOS signaling pathway endows Tregs with increased generation, proliferation, and survival abilities.
Dan-Yang Li +3 more
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Once a Treg, always a Treg? [PDF]
Immunological Reviews, 2014 SummaryRegulatory T cells (Tregs) prevail as a specialized cell lineage that has a central role in the dominant control of immunological tolerance and maintenance of immune homeostasis. Thymus‐derived Tregs (tTregs) and their peripherally induced counterparts (pTregs) are imprinted with unique Forkhead box protein 3 (Foxp3)‐dependent and independent ...
Deepali V, Sawant, Dario A A, Vignali
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Pathological conditions re-shape physiological Tregs into pathological Tregs [PDF]
Burns & Trauma, 2015 AbstractCD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in
Yang, William Y +5 more
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IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses
Frontiers in Immunology, 2020 Despite the great impact on long-term survival of some cancer patients, the immune checkpoint blockade (ICB) therapy is limited by its low response rates for most cancers.
Qiuxia Qu +6 more
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Tregs and allergic disease [PDF]
Journal of Clinical Investigation, 2004 Allergic diseases such as asthma, rhinitis, and eczema are increasing in prevalence and affect up to 15% of populations in Westernized countries. The description of Tregs as T cells that prevent development of autoimmune disease led to considerable interest in whether these Tregs were also normally involved in prevention of sensitization to allergens ...
Douglas S, Robinson +2 more
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Frontiers in Immunology, 2019 Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong correlation between induction of
Roland W. Herzog +4 more
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Pharmaceutical Biology, 2022 Context Many natural extracts have been shown to minimize the toxicity of doxorubicin (Dox). Low piperine Piper nigrum L. (Piperaceae) extract (PFPE) is a natural extract containing many types of antioxidants that may reduce Dox toxicities.
Jirakrit Saetang +7 more
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Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target
Human Vaccines & Immunotherapeutics, 2019 Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri +2 more
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Педиатрическая фармакология, 2013 The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva +4 more
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