Results 31 to 40 of about 167,295 (312)

How sphingolipids affect T cells in the resolution of inflammation

Frontiers in Pharmacology, 2022
The concept of proper resolution of inflammation rather than counteracting it, gained a lot of attention in the past few years. Re-assembly of tissue and cell homeostasis as well as establishment of adaptive immunity after inflammatory processes are the ...
Jennifer Christina Hartel, Jennifer Christina Hartel, Nadine Merz, Sabine Grösch, Sabine Grösch   +4 more
doaj   +1 more source

IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica

Journal of Inflammation Research, 2021
Yang Bai,1,* Fei Guan,1,* Feifan Zhu,1 Chunjie Jiang,1 XiaoXiao Xu,1 Fang Zheng,2 Wenqi Liu,1 Jiahui Lei1 1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ...
Bai Y, Guan F, Zhu F, Jiang C, Xu X, Zheng F, Liu W, Lei J   +7 more
doaj  

Evaluation of the functional activity of CD39 ectonucleotidase in regulatory T cells in children with inflammatory bowel diseases

Медицинская иммунология, 2023
In connection with the increasing incidence and prevalence of inflammatory bowel disease (IBD), the search for prognostic markers of the effectiveness of therapy is an urgent problem. An imbalance between Th17 lymphocytes and regulatory T cells (Treg) is
T. V. Radygina, E. G. Sorokina, S. V. Petrichuk, D. G. Kuptsova, O. V. Kurbatova, A. S. Potapov, S. A. Afanasyeva   +6 more
doaj   +1 more source

Content of CD4⁺T cell subpopulations in predicting the efficacy of biological therapy for psoriasis in children

Медицинская иммунология, 2023
Psoriasis is a chronic inflammatory skin disease characterized by increased proliferation of epidermal cells, impaired keratinization and an inflammatory reaction in dermis caused by activation of T lymphocytes and synthesis of pro-inflammatory cytokines.
D. G. Kuptsova, T. V. Radigina, O. V. Kurbatova, A. I. Materikin, R. V. Epishev, L. A. Opryatin, A. A. Khotko, N. N. Murashkin, S. V. Petrichuk   +8 more
doaj   +1 more source

GP96: safeguarding Treg

Oncotarget, 2015
FOXP3 positive regulatory T cells (Tregs) are key players in maintaining peripheral immune tolerance. Multiple molecules and signaling pathways are involved in regulating Treg function. Understanding these mechanisms is vital to designing Treg-targeted immunotherapeutic strategies for cancer and other diseases. A recent study uncovered that endoplasmic
Yongliang, Zhang, Ephraim, Ansa-Addo, Zihai, Li   +2 more
openaire   +2 more sources

Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]

, 2011
In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core   +1 more source

AGE-DEPENDENT CHANGES OF T-REGULATORY AND Th17 SUBSET LEVELS IN PERIPHERAL BLOOD FROM HEALTHY HUMANS

Медицинская иммунология, 2017
Age-dependent development of Th17 and Treg lymphocyte subsets in healthy  humans is studied insufficiently. The  present  study aimed  to investigate  quantitative characteristics of Th17  and  Treg subsets in peripheral blood of healthy  subjects for ...
A. P. Toptygina, E. L. Semikina, S. V. Petrichuk, R. Sh. Zakirov, O. V. Kurbatova, E. A. Kopyltsova, Yu. А. Komakh   +6 more
doaj   +1 more source

RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS

Медицинская иммунология, 2014
The relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated.
E. R. Chernykh, E. V. Kurganova, M. A. Tikhonova, E. G. Laskavaya, V. A. Lebedeva, A. A. Ostanin   +5 more
doaj   +1 more source

Tregs and transplantation tolerance [PDF]

Journal of Clinical Investigation, 2004
The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes ...
Patrick T, Walsh, Devon K, Taylor, Laurence A, Turka   +2 more
openaire   +2 more sources

Role and specificity of regulatory T cells during retroviral infection [PDF]

, 2009
During chronic viral infection of the hematopoietic system, both virus-mediated and immune-mediated effects may cause bone marrow dysfunction leading to cytopenias. To study the pathological consequences of the T helper response to unresolving chronic
Antunes, I.L., Antunes, I L
core