Results 31 to 40 of about 156,448 (312)

Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report [PDF]

Iranian Journal of Immunology, 2022
Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side ...
Yaghoub Mollaei-Kandelous, Pedram Ahmadpoor, Mohsen Nafar, Mohammad Reza Khatami, Samad Farashi Bonab, Nader Tajik, Mahdi Shekarabi, Aliakbar Amirzargar   +7 more
doaj   +1 more source

The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story

Microorganisms, 2019
The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota.
Hongyu Cheng, Xiong Guan, Dekun Chen, Wentao Ma   +3 more
doaj   +1 more source

Features of parameters of cellular immune depending on the activity of foci of demyelination in children with multiple sclerosis

Медицинская иммунология, 2023
MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults.
T. V. Radygina, D. G. Kuptsova, O. V. Kurbatova, S. V. Petrichuk, E. L. Semikina, A. P. Fisenko, L. M. Abdullaeva, B. I. Bursagova   +7 more
doaj   +1 more source

Increased Plasticity of FOXP3+ Treg under Pathological Conditions Convert Treg into Either Novel Treg or Th1‐Treg

The FASEB Journal, 2018
Naïve CD4+ Th (T helper cells) can differentiate/be polarized in to 9 terminally differentiated Th cell subsets depending on the cytokine repertoire and anatomical location. CD4+ FOXP3+ (forkhead box P3) regulatory T cells (Treg) are one of the Th subsets.
Keman Xu, William Y. Yang, Gayani K. Nanayakkara, Ying Shao, Fan Yang, Wenhui Hu, Eric T. Choi, Hong Wang, Xiaofeng Yang   +8 more
openaire   +1 more source

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications

, 2021
International audienceRegulatory Tcells (Treg) are essential components of peripheral immune homeostasis. Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in preclinical studies and is now moving from phase I/IIa to ...
Amini, Leila, Greig, Jenny, Anegon, Ignacio, Bézie, Séverine, Reinke, Petra, Schmueck-Henneresse, Michael, Guillonneau, Carole, Volk, Hans-Dieter, Wagner, Dimitrios   +8 more
core   +1 more source

Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia

Autoimmunity, 2017
Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency.
Yating Hao, Huiyuan Li, Yang Li, Mingen Lyu, Donglei Zhang, Rongfeng Fu, Yue Guan, Shixuan Wang, Boyang Sun, Xueqing Dou, Renchi Yang   +10 more
doaj   +1 more source

GP96: safeguarding Treg

Oncotarget, 2015
FOXP3 positive regulatory T cells (Tregs) are key players in maintaining peripheral immune tolerance. Multiple molecules and signaling pathways are involved in regulating Treg function. Understanding these mechanisms is vital to designing Treg-targeted immunotherapeutic strategies for cancer and other diseases. A recent study uncovered that endoplasmic
Yongliang, Zhang, Ephraim, Ansa-Addo, Zihai, Li   +2 more
openaire   +2 more sources

The role of galectin-1 and galectin-3 in the mechanisms of T-cell immune response dysregulation in colon cancer

Бюллетень сибирской медицины, 2020
The aim of the study was to characterize the features of the subpopulation composition and cytokine-secretory activity of T lymphocytes (Th1, Th17 and Treg) in relation to the concentration of galectin-1 and galectin-3 in the blood of patients with colon
V. S. Poletika, Yu. V. Kolobovnikova, O. I. Urazova, O. A. Vasileva, A. I. Dmitrieva, K. I. Yankovich, V. V. Novitsky, L. M. Ryabova, M. Yu. Grishchenko   +8 more
doaj   +1 more source

LieberInstitute/TREG: Bioconductor Submission

, 2022
https://github.com/Bioconductor/Contributions/issues ...
Louise Huuki, Leonardo Collado-Torres
core   +1 more source

Tregs and transplantation tolerance [PDF]

Journal of Clinical Investigation, 2004
The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes ...
Patrick T, Walsh, Devon K, Taylor, Laurence A, Turka   +2 more
openaire   +4 more sources