Results 61 to 70 of about 167,295 (312)

LieberInstitute/TREG: Bioconductor Submission

, 2022
https://github.com/Bioconductor/Contributions/issues ...
Louise Huuki, Leonardo Collado-Torres
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity

Immunological Medicine, 2021
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and ...
Agustinus Darmadi Hariyanto, Tiara Bunga Mayang Permata, Soehartati Argadikoesoema Gondhowiardjo   +2 more
doaj   +1 more source

TLRs toll for Tregs [PDF]

Journal of Leukocyte Biology, 2019
Abstract Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy.
openaire   +3 more sources

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

CLEC5a-directed bispecific antibody for effective cellular phagocytosis

mAbs, 2022
While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB).
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng, Juan Zhang, Yongmei Chen, Haochu Huang, Wyne P. Lee, Yan Wu, Minhong Yan   +11 more
doaj   +1 more source

Isolation of Treg cells and Treg cell suppression/death assay

, 2015
<p><em>In vitro</em> Treg suppression assays are performed to determine the functional effect of Treg cells on CD4 T cells. They are performed by co-culturing the responding population (Tresp) with the Treg cells or control CD4 cells ...
sprotocols
core   +1 more source

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection [PDF]

, 2013
Foxp3+ regulatory T (Treg) cells are essential for the maintenance of immune homeostasis and tolerance. During viral infections, Treg cells can limit the immunopathology resulting from excessive inflammation, yet potentially inhibit effective antiviral T
Warren J. Leonard (253168), Schmitz, Iwana, Fröhlich, Anja, Christoph Schneider, Helge Frebel (413362), Warren J. Leonard, Kopf, Manfred, Sparwasser, Tim, Iwana Schmitz (413359), Daniel Christ, Freigang, Stefan, Manfred Kopf, Annette Oxenius (141998), Tim Sparwasser, Annette Oxenius, Stefan Freigang, Helge Frebel, Leonard, Warren J., Oxenius, Annette, Leonard, Warren J, Anja Fröhlich, Anja Fröhlich (413361), Schneider, Christoph, Daniel Christ (22143), Christ, Daniel, Frebel, Helge, Manfred Kopf (224264), Stefan Freigang (413363), Warren J Leonard, Freigang, Stefan Bernd, Iwana Schmitz, Christoph Schneider (413360), Tim Sparwasser (128746)   +32 more
core   +3 more sources

Treg cell-based therapies: challenges and perspectives [PDF]

, 2020
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease.
Jeffrey A. Bluestone, Linda T. Vo, Raffin, Caroline, Bluestone, Jeffrey A, Vo, Linda T, Caroline Raffin   +5 more
core   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source