Results 61 to 70 of about 156,448 (312)

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Depletion of CD25+ cells during acute toxoplasmosis does not significantly increase mortality in Swiss OF1 mice

Memorias do Instituto Oswaldo Cruz, 2012
The interleukin (IL)-2R alpha chain (CD25) is expressed on regulatory T cells (Treg), which constitute more than 85% of the CD25+ T cell population in a naïve mouse.
Haroon Akbar, Stéphanie Germon, Patricia Berthon, Isabelle Dimier-Poisson, Nathalie Moiré   +4 more
doaj   +1 more source

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection [PDF]

, 2013
Foxp3+ regulatory T (Treg) cells are essential for the maintenance of immune homeostasis and tolerance. During viral infections, Treg cells can limit the immunopathology resulting from excessive inflammation, yet potentially inhibit effective antiviral T
Warren J. Leonard (253168), Schmitz, Iwana, Fröhlich, Anja, Christoph Schneider, Helge Frebel (413362), Warren J. Leonard, Kopf, Manfred, Sparwasser, Tim, Iwana Schmitz (413359), Daniel Christ, Freigang, Stefan, Manfred Kopf, Annette Oxenius (141998), Tim Sparwasser, Annette Oxenius, Stefan Freigang, Helge Frebel, Leonard, Warren J., Oxenius, Annette, Leonard, Warren J, Anja Fröhlich, Anja Fröhlich (413361), Schneider, Christoph, Daniel Christ (22143), Christ, Daniel, Frebel, Helge, Manfred Kopf (224264), Stefan Freigang (413363), Warren J Leonard, Freigang, Stefan Bernd, Iwana Schmitz, Christoph Schneider (413360), Tim Sparwasser (128746)   +32 more
core   +1 more source

Treg cell-based therapies: challenges and perspectives [PDF]

, 2020
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease.
Jeffrey A. Bluestone, Linda T. Vo, Raffin, Caroline, Bluestone, Jeffrey A, Vo, Linda T, Caroline Raffin   +5 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity

Immunological Medicine, 2021
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and ...
Agustinus Darmadi Hariyanto, Tiara Bunga Mayang Permata, Soehartati Argadikoesoema Gondhowiardjo   +2 more
doaj   +1 more source

Isolation of Treg cells and Treg cell suppression/death assay

, 2015
<p><em>In vitro</em> Treg suppression assays are performed to determine the functional effect of Treg cells on CD4 T cells. They are performed by co-culturing the responding population (Tresp) with the Treg cells or control CD4 cells ...
sprotocols
core   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

CLEC5a-directed bispecific antibody for effective cellular phagocytosis

mAbs, 2022
While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB).
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng, Juan Zhang, Yongmei Chen, Haochu Huang, Wyne P. Lee, Yan Wu, Minhong Yan   +11 more
doaj   +1 more source

TLRs toll for Tregs [PDF]

Journal of Leukocyte Biology, 2019
Abstract Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy.
openaire   +3 more sources