Results 111 to 120 of about 156,448 (312)
Advanced Science, EarlyView.ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao +12 more
wiley +1 more source
Chinese Journal of Lung Cancer, 2019 Chronic obstructive pulmonary disease (COPD) and lung cancer are global high incidence and high mortality diseases, which seriously increase the socio-economic burden. Smoke exposure, genetic susceptibility and chronic inflammation are common susceptible
Jinhua ZHOU, Wei WANG, Ruijuan LIU
doaj +1 more source
Lkb1 maintains Treg cell lineage identity
, 2017 Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that Lkb1
Xiaolei Sun +19 more
core +1 more source
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
, 2011 The acute phase protein serum amyloid A (SAA) has been well characterized as an indicator of inflammation. Nevertheless, its functions in pro versus anti-inflammatory processes remain obscure.
Jane L. Park +7 more
core +1 more source
Advanced Science, EarlyView.Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan +6 more
wiley +1 more source
Schematic representation of GXMGal effects on Treg (A) and on Treg/Th17 balance (B).
, 2014 Schematic representation of GXMGal effects on Treg (A) and on Treg/Th17 balance (B).
Arturo Casadevall (21382) +9 more
core +1 more source
Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC
Advanced Science, EarlyView.Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang +13 more
wiley +1 more source
Медицинская иммунологияWe have tested the effects of metabolites from paleobacteria Bacillus cereus, strain 875 TS, from Pleistocene-Holocene permafrost rocks aiming to assess the mechanisms and features of in vitro immune response in the culture of human peripheral blood ...
S. A. Pwetrov +5 more
doaj +1 more source
The Dynamics of Treg/Th17 and the Imbalance of Treg/Th17 in Clonorchis sinensis-Infected Mice.
, 2015 Clonorchiasis, caused by the liver fluke Clonorchis sinensis, is a chronic parasitic infection regulated by T cell subsets. An imbalance of CD4+CD25+ Foxp3+regulatory T (Treg) and interleukin (IL)-17-secreting T cells (Th17) may control inflammation and ...
Chao Yan (150844) +23 more
core +1 more source