Results 111 to 120 of about 167,295 (312)

Tregs in Immunotherapy: Opportunities and Challenges [PDF]

Immunotherapy, 2011
n ...
openaire   +3 more sources

Do natural Treg become activated to antigen specific Treg in transplantation and in autoimmunity? [PDF]

, 2013
Antigen specific Treg are often CD4+CD25+FoxP3+T cells, with a phenotype similar to natural Treg (nTreg). It is assumed that nTreg cannot develop into an antigen specific Treg as repeated culture with IL-2 and a specific antigen does not increase the ...
Giang T. Tran, Bruce M. Hall, Karren M. Plain, Masaru eNomura, Masaru Nomura, Nirupama eVerma, Bruce Milne Hall, Catherine M Robinson, Catherine M. Robinson, giang T Tran, Suzanne J Hodgkinson, Karren ePlain, Nirupama D. Verma, Suzanne J. Hodgkinson   +13 more
core   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Immunomodulatory Effect of Fennel in Animal Model of Polycystic Ovarian Syndrome

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2020
Background and Aim: Fennel with phytoestrogenic, antioxidant and anti-diabetic properties is used in traditional Iranian medicine to treat Polycystic Ovarian Syndrome (PCOS).
Ensieh Seif Amirhoseiny, Ali Ganji, Ghasem Mosayebi, Ali Ghazavi   +3 more
doaj  

Research Progress of Treg/Th17 in the Treatment of Chronic Obstructive Pulmonary Disease with Lung Cancer

Chinese Journal of Lung Cancer, 2019
Chronic obstructive pulmonary disease (COPD) and lung cancer are global high incidence and high mortality diseases, which seriously increase the socio-economic burden. Smoke exposure, genetic susceptibility and chronic inflammation are common susceptible
Jinhua ZHOU, Wei WANG, Ruijuan LIU
doaj   +1 more source

Schematic representation of GXMGal effects on Treg (A) and on Treg/Th17 balance (B).

, 2014
Schematic representation of GXMGal effects on Treg (A) and on Treg/Th17 balance (B).
Arturo Casadevall (21382), Alessia Alunno (290618), Eva Pericolini (290617), Siu-Kei Chow (290622), Roberto Gerli (290624), Anna Vecchiarelli (290625), Elena Gabrielli (290619), Stefano Perito (361742), Elena Bartoloni Bocci (648224), Elio Cenci (290621)   +9 more
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Lkb1 maintains Treg cell lineage identity

, 2017
Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that Lkb1
Xiaolei Sun, Yongguang Yang, Yuanyuan Liu, Guogang Xu, Zhongchao Han, Zhina Sun, Huifang Huang, Jingru Liu, Tao Cheng, Wei Guo, Chunxiao Zhao, Qing Niu, Fei Yang, Di Wu, Ting Xue, Fang Liao, Dongming Zhou, Yuechen Luo, Xiaoming Feng, Song Chen   +19 more
core   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source