Results 141 to 150 of about 167,295 (312)

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells [PDF]

Regulatory T (Treg) cells have an immunosuppressive function, and programmed death-1 (PD-1)-expressing Treg cells reportedly induce resistance to PD-1 blockade therapies through their reactivation.
Ueda, Youki, Togashi, Yosuke, Ishino, Takamasa, Honobe-Tabuchi, Akiko, Inozume, Takashi, Matsuura, Hiroaki, Muto, Yoshinori, Ninomiya, Kiichiro, Maeda, Yoshinobu, Nagasaki, Joji, Ninomiya, Toshifumi, Tachibana, Kota, Ohashi, Kadoaki   +12 more
core   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

TREG analysis of ENCODE TF binding data.

, 2013
The GRS concordance analysis between E2+CHX and E2 expression profiles and 494 ENCODE TREG profiles. The solid red line indicates statistical significance cut-off and dashed red line indicates the statistical significance attained with ERα and E2f1 TREG ...
Mukta Phatak (454471), Siva Sivaganesan (79860), John Reichard (454472), Mario Medvedovic (1779), Zhen Hu (394758), Jing Chen (4762), Johannes M. Freudenberg (454473)   +6 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development

Cell Reports
Eos, a member of the Ikaros family of transcription factors, is expressed by T regulatory cells (Tregs) and has been postulated to play a role in Treg suppression and maintenance of Treg stability. We demonstrate that expression of Eos was limited to a subpopulation of thymus-derived, activated Tregs and is undetectable in resting or activated T ...
Xuan Xie, Angela M. Thornton, Shalini Tanwar, Patricia Korty, Alexandria C. Wells, Elisha Segrist, Ana Teijeiro, Claudia A. Rivera, Danping Wei, Xi Chen, Jinfang Zhu, Asya Khleborodova, Tom Hill, Tovah E. Markowitz, Margery Smelkinson, Juraj Kabat, Tibor Veres, Owen M. Schwartz, Francisco Otaizo-Carrasquero, Paul Gardina, Amirhossein Shamsaddini, Craig Martens, Kyoungin Cho, Cheng-Chao Lin, Jaspal S. Khillan, Yelena Levin, Ying Wu, Ethan M. Shevach   +27 more
openaire   +2 more sources

Alteration of Treg compartments in HIV+ and healthy individuals.

, 2019
(A) Frequencies and (B) absolute numbers (AbsN) of Treg, activated Treg (Treg Act+: CD25+CD127negHLA-DR+CD45RO+) and Treg TemRA (CD25+CD127negCD27negCD45RA+) were determined in whole blood using cell surface labeling.
Verónica Pérez-Fernández (6519359), Marjorie Pion (153357), Adrián Prieto-Sánchez (5703779), Rafael Correa-Rocha (846632), Carolina Gutiérrez (192894), Santiago Moreno-Guillen (5703782), Jacobo Lopez-Abente (5703770), María-Ángeles Muñoz-Fernández (5703785)   +7 more
core   +1 more source