Results 161 to 170 of about 275,584 (397)

Natural Tregs and autoimmunity

Frontiers in Bioscience, 2009
The subset of CD4+ T lymphocytes that coexpress high levels of the interleukin (IL)-2 a receptor and the transcription factor Foxp3, commonly called regulatory T cells (Tregs), have a key role in the mechanisms of peripheral immune tolerance. Tregs modulate innate and adaptive immune responses in vitro and in vivo by suppressing the proliferation and ...
openaire   +2 more sources

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
Chai, Zhi, Ciric, Bogoljub, Curtis, Mark T., Guo, Min-Fang, Li, Rui-Lan, Li, Yan-Hua, Ma, Cun-Gen, Rostami, A. M., Song, Guo-Bin, Sun, Man-Luan, Thome, Rodolfo, Xu, Fang, Zhang, Guang-Xian   +12 more
core   +1 more source

MiR-568 inhibits the activation and function of CD4+ T cells and Treg cells by targeting NFAT5 [PDF]

, 2013
Wei Li, Lingbo Kong, Juntang Li, Zhangyan Guo, Qian Xue, Tao Yang, Yan–Ling Meng, Boquan Jin, Weihong Wen, Angang Yang   +9 more
openalex   +1 more source

Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires

European Journal of Immunology, 2019
The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios− Treg were induced from Foxp3− T conventional (Tconv) cells in the periphery ...
A. Thornton, Jinghua Lu, P. Korty, Y. Kim, C. Martens, P. Sun, E. Shevach   +6 more
semanticscholar   +1 more source

Tregitopes switch on Tregs

Blood, 2008
In this issue of Blood, De Groot and colleagues report the identification and functional characterization of Tregitopes, which are Treg-activating regions in the Fc portion of the IgG molecule. This important finding has the potential to bring understanding about a number of phenomena related to Ig, including tolerance to Ab variable regions, the ...
openaire   +3 more sources

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

In vitro effects of paleobacteria exometabolites from permafrost soils on development of immune response

Медицинская иммунология
We have tested the effects of metabolites from paleobacteria Bacillus cereus, strain 875 TS, from Pleistocene-Holocene permafrost rocks aiming to assess the mechanisms and features of in vitro immune response in the culture of human peripheral blood ...
S. A. Pwetrov, L. F. Kalyonova, Yu. G. Sukhovey, E. G. Kostolomova, A. S. Bazhin, M. V. Narushko   +5 more
doaj   +1 more source

Effects of Interferon on PD-1/PD-L1 and Treg Expression in JAK2 V617F-positive Myeloproliferative Neoplasms

Zhongliu Fangzhi Yanjiu, 2019
Objective To explore the effect of interferon-alpha-2b(IFN-alpha 2b) on the expression of programmed death receptor-1(PD-1), programmed death ligand-1(PD-L1) and CD4+ CD25+ Foxp3+ regulatory T cell (Treg) in JAK2 V617F-positive myeloproliferative ...
ZHANG Lijun, QI Feng, CHENG Zhiyong, ZHANG Zhao, WU Shijie, GUO Yantao, SUN Li'na, PENG Zhanxian, LIANG Wentong   +8 more
doaj   +1 more source