Results 271 to 280 of about 275,584 (397)

Reduced Th1 and Treg immune responses in a pediatric egg-allergic group susceptible for an OIT protocol [PDF]

, 2013
Inmaculada Expósito, M. Reche, Teresa Valbuena, A. Padial, Cristina Pascual, Laura Perezábad, Rosina López‐Fandiño, Elena Molina   +7 more
openalex   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Pharmacological mechanisms of traditional Chinese medicine metabolites in regulating Treg cells: an integrative pathway review. [PDF]

Front Pharmacol
Wang C, Liao MJ, Wu Y, Lin H, Ye ZZ, Ma WZ, Yuan Q.   +6 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera. [PDF]

Mol Biomed
Zeng Y, Chen X, Huang W, Chan CH, Chen Z, Lyu M, Liu Y, Liu M, Lyu A, Mauro C, Yu Y, Cheung KC.   +11 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Prognostic value of tumour-associated neutrophils in different polarization status releasing neutrophil extracellular traps in the immunotherapy of advanced non-small cell lung cancer. [PDF]

Front Oncol
Hong W, Ye X, Chen L, Chai X, Yin Y, Li Z, Fang C, Qian X, Yu B, Qin G, Yao X, Zhou B, Luo C, Shu C, Chen D, Li Y, Wang Y.   +16 more
europepmc   +1 more source

Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice

, 2020
Lingzhi Li, Zhifeng Fang, Zongmin Liu, Jianxin Zhao, Hao Zhang, Shunyu Wang, Jianxin He, Wenwei Lu, Wei Chen   +8 more
openalex   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review. [PDF]

Front Immunol
Hu Y, Zhao Q, Dai H, Wu Y, Tang X, Zhang N, Jiang H, Rui H, Liu B.   +8 more
europepmc   +1 more source