Results 1 to 10 of about 203,023 (389)

Cyclophosphamide abrogates the expansion of CD4+Foxp3+ regulatory T cells and enhances the efficacy of bleomycin in the treatment of mouse B16-F10 melanomas

Cancer Biology & Medicine, 2021
Objective: Promotion of the proliferative expansion of CD4+Foxp3+ regulatory T cells (Tregs) is one of the side effects that limits the use of bleomycin (BLM) in the treatment of tumors. In this study, we examined the hypothesis that cyclophosphamide (CY)
Ping Li, Fengyang Chen, Jingbin Zheng, Yang Yang, Yuan Li, Yifei Wang, Xin Chen   +6 more
doaj   +1 more source

Mycobacterium tuberculosis Methyltransferase Rv1515c Can Suppress Host Defense Mechanisms by Modulating Immune Functions Utilizing a Multipronged Mechanism

Frontiers in Molecular Biosciences, 2022
Mycobacterium tuberculosis (M. tb) gene Rv1515c encodes a conserved hypothetical protein exclusively present within organisms of MTB complex and absent in non-pathogenic mycobacteria.
Anshu Rani, Anshu Rani, Anwar Alam, Faraz Ahmad, Manjunath P., Abhinav Saurabh, Sheeba Zarin, Dipendra Kumar Mitra, Seyed E. Hasnain, Seyed E. Hasnain, Nasreen Z. Ehtesham   +10 more
doaj   +1 more source

Exploring the role CD163-labeled TAMs and FOXP3-labeled Tregs in different types of breast cancer: Reflections and putative benefits

Indian Journal of Pathology and Microbiology, 2021
Context: Tumor immune microenvironment (TIME) is heterogeneous and dynamic. It exerts bimodal pro and antitumor effects. Among the TIME contributors, TAMs and Tregs are condemned as cancer cells allies rather than enemies; however, such contribution is ...
Lobna S Shash, Khaled A M. Kamal, Nermine M Abd Raboh   +2 more
doaj   +1 more source

CD24+ MDSC-DCs Induced by CCL5-Deficiency Showed Improved Antitumor Activity as Tumor Vaccines

Global Medical Genetics, 2022
Background Dendritic cell (DC) tumor vaccine has been extensively utilized in preclinical and clinical studies; however, this technique has encountered many difficulties, particularly in late-stage tumor patients.
Lei Huang, Zequn Ding, Yan Zhang
doaj   +1 more source

HMGB1 Signaling-Mediated Tumor Immunity in Cancer Progress

Frontiers in Bioscience-Landmark, 2023
Tumor immunity is a cycle that begins with the release of antigens from tumor cells and ends with the destruction of tumor cells. High mobility group box 1 (HMGB1) is a nonhistone protein widely present in the nucleus of mammalian cells and can be ...
Jinlin Wen, Xinyan Zhang
doaj   +1 more source

Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation

Frontiers in Pharmacology, 2021
Atherosclerosis (AS) is the main pathological cause of acute cardiovascular and cerebrovascular diseases, such as acute myocardial infarction and cerebral apoplexy.
Zhao Gao, Zhao Gao, Xinrui Xu, Yang Li, Kehan Sun, Manfang Yang, Qingyue Zhang, Shuqi Wang, Yiyi Lin, Lixia Lou, Aiming Wu, Weijing Liu, Weijing Liu, Bo Nie, Bo Nie   +14 more
doaj   +1 more source

T regulatory lymphocytes and endothelial function in pediatric obstructive sleep apnea. [PDF]

, 2013
BackgroundObstructive sleep apnea (OSA) is a low-grade inflammatory disease affecting the cardiovascular and metabolic systems. Increasing OSA severity reduces T-regulatory lymphocytes (Tregs) in OSA children. Since Tregs modulate endothelial activation,
Bandla, Hari PR, Bhattacharjee, Rakesh, Gozal, David, Kheirandish-Gozal, Leila, Kulkarni, Richa, Ramirez, Helena Molero, Samiei, Arash, Tan, Hui-Leng, Wang, Yang   +8 more
core   +7 more sources

VIP Promotes Recruitment of Tregs to the Uterine–Placental Interface During the Peri-Implantation Period to Sustain a Tolerogenic Microenvironment

Frontiers in Immunology, 2020
Uterine receptivity and embryo implantation are two main processes that need a finely regulated balance between pro-inflammatory and tolerogenic mediators to allow a successful pregnancy.
Lucila Gallino, Vanesa Hauk, Laura Fernández, Elizabeth Soczewski, Soledad Gori, Esteban Grasso, Guillermina Calo, Nora Saraco, Esperanza Berensztein, James A. Waschek, Claudia Pérez Leirós, Rosanna Ramhorst   +11 more
doaj   +1 more source

Diminished Pneumococcal-Specific CD4+ T-Cell Response is Associated With Increased Regulatory T Cells at Older Age

Frontiers in Aging, 2021
Respiratory infection caused by Streptococcus pneumoniae is a leading cause of morbidity and mortality in older adults. Acquired CD4+ T cell mechanism are essential for the protection against colonization and subsequent development of infections by S ...
Samantha W. J. He, Martijn D. B. van de Garde, Daan K. J. Pieren, Martien C. M. Poelen, Franziska Voß, Mohammed R. Abdullah, Sven Hammerschmidt, Cécile A. C. M. van Els   +7 more
doaj   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources