Results 121 to 130 of about 130,982 (298)

Targeting Inflammatory T Cells in Multiple Sclerosis: Current Therapies and Future Challenges [PDF]

, 2015
Multiple Sclerosis (MS) is an autoimmune inflammatory disorder of the Central Nervous System (CNS), affecting more than one million people worldwide. The pathogenesis of MS involves several genetic and environmental factors, which ultimately lead to ...
Tuosto, Loretta
core   +1 more source

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
wiley   +1 more source

Oral tolerance in the absence of naturally occurring Tregs [PDF]

, 2005
Daniel Mucida
openalex   +1 more source

A Silk Fibroin Nanoparticle Hydrogel Loaded With NK1R Antagonist Has Synergistic Anti‐Inflammatory and Reparative Effects on Dry Eye Disease

Advanced Science, Volume 12, Issue 15, April 17, 2025.
This study develops a silk fibroin (SF) nanoparticles hydrogel targeting neurokinin 1 receptor with CP‐99994 (CP). Combining CP and SF to form stable nanoparticles while incorporating a flexible hydrogel material results in a sustained‐release ophthalmic drop formulation (SF@CP@Gel), which provides a long‐lasting ophthalmic formulation with anti ...
Bo Gong, Yi Liu, Huan Li, Xueming Ju, Dongfeng Li, Yuhao Zou, Xiaoxin Guo, Kai Dong, Jialing Xiao, Weijia Wu, Renjie Chai, Ruifan Zhang, Man Yu   +12 more
wiley   +1 more source

The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo [PDF]

, 2005
Aysefa Doganci, Tatjana Eigenbrod, Norbert Krug, George T. De Sanctis, Michael Hausding, Veit J. Erpenbeck, El‐Bdaoui Haddad, Edgar Schmitt, Tobias Bopp, Karl-J. Kallen, Udo Herz, Steffen Schmitt, Cornelia Luft, Olaf Hecht, Jens M. Hohlfeld, Hiroaki Ito, Norihiro Nishimoto, Kazuyuki Yoshizaki, Tadamitsu Kishimoto, Stefan Rose‐John, Harald Renz, Markus F. Neurath, Peter R. Galle, Susetta Finotto   +23 more
openalex   +1 more source

Single‐Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic Immunosuppression

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Lung is the most susceptible target organ in sepsis, here, the pulmonary immune landscape of immunosuppressive sepsis patients is showed through scRNA‐seq. The CXCR2+ neutrophil subpopulation can be recruited by CXCL8, and further differentiate into the immunosuppressive CD274+IL1RN+ subpopulation in lung.
Rong Shen, Yi Jiang, Guanglong Liu, Shenjia Gao, Hao Sun, Xinyi Wu, Jiahui Gu, Han Wu, Ke Mo, Xing Niu, Ronen Ben‐Ami, Wanjing Shang, Jie Zhang, Jun Wang, Changhong Miao, Zhizhang Wang, Wankun Chen   +16 more
wiley   +1 more source

Role of IFN-g in induction of Foxp3 and conversion of CD4+CD25- T cells to CD4+ Tregs [PDF]

, 2006
Zhaojun Wang
openalex   +1 more source

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

PTEN inhibits IL-2 receptor-mediated expansion of CD4+CD25+ Tregs [PDF]

, 2006
Patrick Walsh
openalex   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source