Results 121 to 130 of about 203,023 (389)

IL18 signaling promotes homing of mature Tregs into the thymus

eLife, 2020
Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitute a
Cristina Peligero-Cruz, Tal Givony, Arnau Sebé-Pedrós, J. Dobeš, Noam Kadouri, Shir Nevo, Francesco Roncato, R. Alon, Y. Goldfarb, J. Abramson   +9 more
semanticscholar   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer

OncoImmunology, 2020
Oncogenic KRAS-mutant lung cancers remain treatment refractory. A better understanding of the immune response of KRAS-mutant lung cancers is required to facilitate the development of potential therapeutic strategies.
Byung-Seok Kim, Jelita Clinton, Qing Wang, Seon Hee Chang   +3 more
doaj   +1 more source

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming [PDF]

, 2015
Foxp3(+) regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular dynamics of endogenous Tregs.
Cahalan, Michael D, Deswarte, Kim, Dong, Tobias X, Greenberg, Milton L, Hammad, Hamida, Lambrecht, Bart, Matheu, Melanie, Othy, Shivashankar, Parker, Ian, Schuijs, Martijn   +9 more
core   +3 more sources

Regulatory impairment in untreated Parkinson’s disease is not restricted to Tregs: other regulatory populations are also involved

Journal of Neuroinflammation, 2019
Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world. Various studies have suggested that the immune response plays a key role in this pathology.
Diana D Álvarez-Luquín, A. Arce-Sillas, Jaquelín Leyva-Hernández, E. Sevilla-Reyes, M. Boll, Esteban Montes-Moratilla, Viridiana Vivas-Almazán, C. Pérez-Correa, Ulises Rodríguez-Ortiz, Raquel Espinoza-Cárdenas, G. Fragoso, E. Sciutto, L. Adalid-Peralta   +12 more
semanticscholar   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

CD226 opposes TIGIT to disrupt Tregs in melanoma.

JCI Insight, 2018
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT).
J. Fourcade, Zhaojun Sun, Joe-Marc Chauvin, Mignane B. Ka, D. Davar, Ornella Pagliano, Hong Wang, S. Saada, Carmine Menna, Rada Amin, C. Sander, J. Kirkwood, A. Korman, H. Zarour   +13 more
semanticscholar   +1 more source

Tissue Tregs.

Immunology, 2020
FoxP3+ CD4+ Regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti-pathogenic and anti-self responses.
Prudence PokWai Lui, Inchul Cho, N. Ali
semanticscholar   +1 more source