Results 141 to 150 of about 130,982 (298)

Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma

Advanced Science, Volume 12, Issue 15, April 17, 2025.
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye

Advanced Science, Volume 12, Issue 16, April 24, 2025.
A new strategy for constructing smart gel‐based MN patches is developed to overcome the insufficient drug delivery of eye drops to the lacrimal gland. The gel‐based MN patches achieved long‐acting drug release in a ROS‐responsive manner, and separable base in a temperature‐responsive manner.
Jingqing Mu, Xiangyu Ding, Yapeng Song, Baoyue Mi, Xiaolong Fang, Baihua Chen, Bin Yao, Xuguang Sun, Xiaoyong Yuan, Shutao Guo, Xia Hua   +10 more
wiley   +1 more source

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase [PDF]

, 2007
Madhav Sharma, Babak Baban, Phillip Chandler, De-Yan Hou, Nagendra Singh, Hideo Yagita∥, Miyuki Azuma, Bruce R. Blazar, Andrew L. Mellor, David H. Munn   +9 more
openalex   +1 more source

Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

Advanced Science, EarlyView.
Lactobacillus johnsonii and its associated purine metabolite inosine not only restrict systemic B cell differentiation, but also contribute to immune cell infiltration in the kidneys, thereby serving dual functions in mitigating the progression of systemic lupus erythematosus (SLE).
Lingyu Gao, Yuhan Zhang, Zhi Hu, Shengwen Chen, Qiaolin Wang, Yong Zeng, Huiqi Yin, Junpeng Zhao, Yijing Zhan, Changxing Gao, Yue Xin, Bing Chen, Stijn van der Veen, Ming Zhao, Deyu Fang, Qianjin Lu   +15 more
wiley   +1 more source

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

, 2002
E. Allison Green, Yongwon Choi, Richard A. Flavell   +2 more
openalex   +1 more source

Human Peripheral Blood T Regulatory Cells (Tregs), Functionally Primed CCR4+ Tregs and Unprimed CCR4− Tregs, Regulate Effector T Cells Using FasL [PDF]

, 2007
Dolgor Baatar, Purevdorj B. Olkhanud, Kenya Sumitomo, Dennis D. Taub, Ronald E. Gress, Arya Biragyn   +5 more
openalex   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Functional and phenotypic characteristics of CD4⁺CD25^highFoxp3⁺ Treg clones obtained from peripheral blood of patients with cancer [PDF]

, 2007
Laura Strauss, Christoph Bergmann, Theresa L. Whiteside   +2 more
openalex   +1 more source

Osteosarcoma Cell‐Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu, Lei Li, Xiaoming Bai, Mengxue Zhang, Wei Lv, Yongbin Ma, Yuzhi Sun, Hongjing Zhang, Qing Jiang, Qingqiang Yao, Zhi‐Yuan Zhang   +10 more
wiley   +1 more source

Cytokine Couture: Designer IL2 Molecules for the Treatment of Disease

ImmunoTargets and Therapy
Amy Dashwood,1,2 Arman Ali Ghodsinia,1 James Dooley,1 Adrian Liston1 1Department of Pathology, University of Cambridge, Cambridge, UK; 2Immunology Programme, Babraham Institute, Cambridge, UKCorrespondence: Amy Dashwood; Email ajd241@cam.ac.uk Adrian ...
Dashwood A, Ghodsinia AA, Dooley J, Liston A   +3 more
doaj