Results 161 to 170 of about 130,982 (298)

Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen [PDF]

, 2007
Jin Zheng, M. Eric Kohler, Qingrong Chen, James J. Weber, Javed Khan, Bryon D. Johnson, Rimas J. Orentas   +6 more
openalex   +1 more source

UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation

Advanced Science, Volume 12, Issue 16, April 24, 2025.
UniMap introduces a novel multiselective adversarial network that functions as a discerner in single‐cell dataset integration. It enables type‐level integration, ensuring accurate cell type annotation across diverse biological contexts while preserving shared and domain‐specific features.
Haitao Hu, Yue Guo, Fujing Ge, Hao Yin, Hao Zhang, Zhesheng Zhou, Fangjie Yan, Qing Ye, Jialu Wu, Ji Cao, Chang‐Yu Hsieh, Bo Yang   +11 more
wiley   +1 more source

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

Advanced Science, Volume 12, Issue 16, April 24, 2025.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun   +15 more
wiley   +1 more source

Isolation of Treg cells and Treg cell suppression/death assay [PDF]

, 2007
Pushpa Pandiyan
openalex   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Deficient SOCS3 expression in CD4⁺CD25⁺FoxP3⁺ regulatory T cells and SOCS3‐mediated suppression of Treg function [PDF]

, 2007
Brendan B. L. Pillemer, Hui Xu, Timothy B. Oriss, Zengbiao Qi, Anuradha Ray   +4 more
openalex   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

353: Thymoglobulin stimulates Th2-type alloresponses and preserves regulatory T cell (Treg) function in-vitro [PDF]

, 2007
D. Mahmud, Sandeep Chunduri, John Maciejewski, Ronak Iqbal, Damiano Rondelli   +4 more
openalex   +1 more source

NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis

Advanced Science, Volume 12, Issue 16, April 24, 2025.
In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu, Kang Ning, Zhaohao Huang, Binyao Chen, Junjie Chen, Yingying Wen, Jian Bu, Han Hong, Qiaorong Chen, Zhuoqi Zhang, Renbing Jia, Wenru Su   +11 more
wiley   +1 more source

TARGETING ACUTE HEART ALLOGRAFT REJECTION BY IMMUNOTHERAPY OF EX VIVO-EXPANDED NATURAL FOXP3+CD4+CD25+ REGULATORY T (Treg) CELLS IN MICE.

, 2006
NULL AUTHOR_ID
openalex   +1 more source