Results 11 to 20 of about 203,023 (389)

ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases [PDF]

Frontiers in Immunology, 2020
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells.
Dan-yang Li, X. Xiong
semanticscholar   +4 more sources

Tissue Tregs. [PDF]

Annual Review of Immunology, 2016
The immune system is responsible for defending an organism against the myriad of microbial invaders it constantly confronts. It has become increasingly clear that the immune system has a second major function: the maintenance of organismal homeostasis. Foxp3+CD4+regulatory T cells (Tregs) are important contributors to both of these critical activities,
Marisella Panduro, C. Benoist, D. Mathis
semanticscholar   +3 more sources

Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions [PDF]

Cellular & Molecular Immunology, 2020
The vast majority of Foxp3+ regulatory T cells (Tregs) are generated in the thymus, and several factors, such as cytokines and unique thymic antigen-presenting cells, are known to contribute to the development of these thymus-derived Tregs (tTregs).
Eirini Nikolouli, Yassin Elfaki, Susanne Herppich, Carsten Schelmbauer, Michael Delacher, C. Falk, I. Mufazalov, A. Waisman, M. Feuerer, J. Huehn   +9 more
semanticscholar   +4 more sources

Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders – Advances and challenges

Human Vaccines & Immunotherapeutics, 2022
Autoimmune diseases are caused when immune cells act against self-protein. This biological self–non-self-discrimination phenomenon is controlled by a distinct group of lymphocytes known as regulatory T cells (Tregs), which are key inflammatory response ...
T. Goswami, Mithilesh Singh, Manish Dhawan, Saikat Mitra, T. Emran, A. Rabaan, A. A. Mutair, Z. A. Alawi, S. Alhumaid, K. Dhama   +9 more
semanticscholar   +1 more source

Regulatory T Cells (Tregs) and COVID-19: Unveiling the Mechanisms, and Therapeutic Potentialities with a Special Focus on Long COVID

Vaccines, 2023
The COVID-19 pandemic has caused havoc all around the world. The causative agent of COVID-19 is the novel form of the coronavirus (CoV) named SARS-CoV-2, which results in immune system disruption, increased inflammation, and acute respiratory distress ...
Manish Dhawan, A. Rabaan, S. Alwarthan, Mashael Alhajri, Muhammad A. Halwani, Amer M Alshengeti, Mustafa A. Najim, A. S. Alwashmi, Ahmad A. Alshehri, Saleh Alshamrani, B. Alshehail, Mohammed A. Garout, Saleh Al-Abdulhadi, Shamsah H. Al-Ahmed, Nanamika Thakur, Geetika Verma   +15 more
semanticscholar   +1 more source

Regulatory T cells (Tregs) in liver fibrosis

Cell Death Discovery, 2023
The ability of the human liver to both synthesize extracellular matrix(ECM), as well as regulate fibrogenesis, are integral functions to maintaining homoeostasis.
Ke-jia Wu, Q. Qian, Jinxing Zhou, Donglin Sun, Yun-fei Duan, Xi Zhu, Kurt Sartorius, Yunjie Lu   +7 more
semanticscholar   +1 more source

Tregs dysfunction aggravates postoperative cognitive impairment in aged mice

Journal of Neuroinflammation, 2023
Objectives Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses.
Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi, Hao Fang   +8 more
semanticscholar   +1 more source

Tregs in transplantation tolerance: role and therapeutic potential

Frontiers in Transplantation, 2023
CD4+ Foxp3+ regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and they play a role in cancer and transplantation settings by restraining immune responses.
Alexandra Cassano, A. Chong, M. Alegre
semanticscholar   +1 more source

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

Journal for ImmunoTherapy of Cancer, 2022
Background The Regulatory T cell (Treg) lineage is defined by the transcription factor FOXP3, which controls immune-suppressive gene expression profiles.
A. Revenko, L. Carnevalli, C. Sinclair, Ben Johnson, A. Peter, Molly A. Taylor, Lisa Hettrick, Melissa Chapman, Stephanie K. Klein, A. Solanki, D. Gattis, A. Watt, Adina M. Hughes, Lukasz Magiera, G. Kar, Lucy Ireland, Deanna A. Mele, V. Sah, Maneesh Singh, Joseph Walton, Maelle Mairesse, M. King, P. Lyne, S. Barry, S. Fawell, Frederick W. Goldberg, A. Macleod, Tracy Reigle, Raul Alonzo   +28 more
semanticscholar   +1 more source

Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target

bioRxiv, 2022
The quality of the immune infiltrate of intrahepatic cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly characterized, limiting development of successful immunotherapies.
Giorgia Alvisi, A. Termanini, C. Soldani, F. Portale, R. Carriero, K. Pilipow, G. Costa, M. Polidoro, B. Franceschini, Ines Malenica, S. Puccio, Veronica Lise, G. Galletti, V. Zanon, F. Colombo, G. De Simone, Michele Tufano, A. Aghemo, L. di Tommaso, C. Peano, J. Cibella, M. Iannacone, R. Roychoudhuri, T. Manzo, M. Donadon, G. Torzilli, P. Kunderfranco, Diletta Di Mitri, E. Lugli, A. Lleo   +29 more
semanticscholar   +1 more source