Results 11 to 20 of about 130,982 (298)

Galectin‐1‐Induced Tumor Associated Macrophages Repress Antitumor Immunity in Hepatocellular Carcinoma Through Recruitment of Tregs

Advanced Science
Tumor‐associated macrophages (TAMs) are commonly considered accomplices in tumorigenesis and tumor development. However, the precise mechanism by which tumor cells prompt TAMs to aid in evading immune surveillance remains to be further investigated. Here,
Xizhi Yu, Junjie Qian, Limin Ding, Caixu Pan, Xi Liu, Qinchuan Wu, Shuai Wang, Jianpeng Liu, Mingge Shang, Rong Su, Danjing Guo, Haiyang Xie, Shengyong Yin, Lin Zhou, Shusen Zheng   +14 more
doaj   +2 more sources

T regulatory lymphocytes and endothelial function in pediatric obstructive sleep apnea. [PDF]

, 2013
BackgroundObstructive sleep apnea (OSA) is a low-grade inflammatory disease affecting the cardiovascular and metabolic systems. Increasing OSA severity reduces T-regulatory lymphocytes (Tregs) in OSA children. Since Tregs modulate endothelial activation,
Bandla, Hari PR, Bhattacharjee, Rakesh, Gozal, David, Kheirandish-Gozal, Leila, Kulkarni, Richa, Ramirez, Helena Molero, Samiei, Arash, Tan, Hui-Leng, Wang, Yang   +8 more
core   +10 more sources

In utero Therapy for the Treatment of Sickle Cell Disease: Taking Advantage of the Fetal Immune System

Frontiers in Cell and Developmental Biology, 2021
Sickle Cell Disease (SCD) is an autosomal recessive disorder resulting from a β-globin gene missense mutation and is among the most prevalent severe monogenic disorders worldwide.
Alba Saenz de Villaverde Cortabarria, Laura Makhoul, John Strouboulis, Giovanna Lombardi, Eugene Oteng-Ntim, Panicos Shangaris, Panicos Shangaris   +6 more
doaj   +1 more source

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]

, 2016
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo, CARONNA, Roberto, CHIRLETTI, Piero, CIARDI, Antonio, DEL BENE, GABRIELLA, FARELLI, FRANCESCO, Focaccetti, Chiara, Longo, Flavia, MORELLI, Sergio, PACELLA, ILENIA, PICONESE, SILVIA, SACCO, LUCA, SCHINZARI, VALERIA, TIMPERI, ELEONORA, VESTRI, Anna Rita   +14 more
core   +1 more source

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

OncoImmunology, 2022
Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith, William W. Lockwood   +21 more
doaj   +1 more source

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease [PDF]

, 2019
Soluble stimulation-2 (ST2) is increased during graft-versus-host disease (GVHD), while Tregs that express ST2 prevent GVHD through unknown mechanisms.
Blazar, Bruce R., Griesenauer, Brad, Hippen, Keli L., Liu, Hong, Loschi, Michael, Paczesny, Sophie, Ramadan, Abdulraouf, Reichenbach, Dawn K., Yang, Jinfeng, Zhang, Jilu   +9 more
core   +1 more source

Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation?

Journal of Transplantation, 2012
The existence of T-cell subsets naturally committed to perform immunoregulation has led to enthusiastic efforts to investigate their role in the immunopathogenesis of transplantation. Being able to modulate alloresponses, regulatory T cells could be used
Francisco Salcido-Ochoa, Nurhashikin Yusof, Susan Swee-Shan Hue, Doreen Haase, Terence Kee, Olaf Rotzschke   +5 more
doaj   +1 more source

Mathematical modeling of tumor-immune system interactions: the effect of rituximab on breast cancer immune response [PDF]

, 2021
tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as well as CD8$^+$ T cells, CD4$^+$ T ...
arxiv   +1 more source

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming [PDF]

, 2015
Foxp3(+) regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular dynamics of endogenous Tregs.
Cahalan, Michael D, Deswarte, Kim, Dong, Tobias X, Greenberg, Milton L, Hammad, Hamida, Lambrecht, Bart, Matheu, Melanie, Othy, Shivashankar, Parker, Ian, Schuijs, Martijn   +9 more
core   +3 more sources