Results 61 to 70 of about 203,023 (389)

The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis

Virulence, 2020
Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation, Akram A. Da’Dara, Patrick J. Skelly   +2 more
doaj   +1 more source

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner [PDF]

, 2019
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-kappa B and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions.
Baens, Mathijs, Beyaert, Rudi, Demeyer, Annelies, Driege, Yasmine, Hochepied, Tino, Kreike, Marja, Skordos, Ioannis, Staal, Jens   +7 more
core   +2 more sources

Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4⁺ T Cells

Vaccines, 2019
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and it exhibits resistance to common breast cancer therapies. Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and its ligand, PD-L1, have been
Reem Saleh, Salman M Toor, Sarah Khalaf, Eyad Elkord   +3 more
doaj   +1 more source

Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients

OncoImmunology, 2020
The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying immune mechanisms impacting survival of HCC patients have not been investigated.
Suresh Gopi Kalathil, Katy Wang, Alan Hutson, Renuka Iyer, Yasmin Thanavala   +4 more
doaj   +1 more source

Expansion of CD25-Negative Forkhead Box P3-Positive T Cells during HIV and Mycobacterium tuberculosis Infection [PDF]

, 2017
Tuberculosis (TB) and HIV alter the immune system, and coinfected (HIV-TB) individuals usually present deregulations of T-lymphocytic immune response.
Ameri, Diego, Angerami, Matias, Ben, Graciela, Laufer, Natalia Lorna, Perez, Hector, Quiroga, María Florencia, Salomon, Horacio Eduardo, Sued, Omar Gustavo, Suárez, Guadalupe Verónica, Vecchione, María Belén   +9 more
core   +2 more sources

Targeting tumor-infiltrating tregs for improved antitumor responses

Frontiers in Immunology
Immunotherapies have revolutionized the landscape of cancer treatment. Regulatory T cells (Tregs), as crucial components of the tumor immune environment, has great therapeutic potential.
Diyuan Qin, Yugu Zhang, Pei Shu, Yanna Lei, Xiaoyu Li, Yongsheng Wang   +5 more
semanticscholar   +1 more source

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Distant metastasis is the major cause of mortality in patients with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy. Local radiotherapy can trigger an abscopal response to metastatic tumor cells.
D. Ji, Can Song, Yongheng Li, Jinhong Xia, Yanjing Wu, Jinying Jia, Xinxin Cui, Songmao Yu, J. Gu   +8 more
semanticscholar   +1 more source

RETRACTED: Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction

Frontiers in Immunology, 2023
BackgroundTregs plays a critical role in the development of secondary injuries in diseases. Accumulating evidence suggests an association between ischemic stroke and renal dysfunction; however, the underlying mechanisms remain unclear.
Shuai Wang, Yubin Shi, Yanqi Zhang, Fengyun Yuan, Mintao Mao, Jun Ma   +5 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma

Cancer Biology & Medicine, 2021
Objective: L1 cell adhesion molecule (L1CAM) exhibits oncogenic activity in tumors. However, the link between L1CAM and the tumor microenvironment remains poorly understood in patients with esophageal squamous cell carcinoma (ESCC).
Xuan Zhao, Shasha Liu, Xinfeng Chen, Jianyi Zhao, Feng Li, Qitai Zhao, Tan Xie, Lan Huang, Zhen Zhang, Yu Qi, Yang Yang, Song Zhao, Yi Zhang   +12 more
doaj   +1 more source