Results 131 to 140 of about 129,119 (300)

Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics

Brain Sciences
Background: Tremor is a common but diagnostically challenging movement disorder due to its clinical heterogeneity and overlapping aetiologies.
Emmanuel Ortega-Robles, Oscar Arias-Carrión   +1 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

The digital signature of emergent tremor in Parkinson’s disease

npj Parkinson's Disease
Emergent tremor in Parkinson’s disease (PD) can occur during sustained postures or movements that are different from action tremor. Tremor can contaminate the clinical rating of bradykinesia during finger tapping.
Aryaman S. Gala, Kevin B. Wilkins, Matthew N. Petrucci, Yasmine M. Kehnemouyi, Anca Velisar, Megan H. Trager, Helen M. Bronte-Stewart   +6 more
doaj   +1 more source

Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles

BMEMat, EarlyView.
Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu, Nan Li, Yu Chen, Rui Pu, Wei Wei, Yunqi Lin, Lejing Li, Yao Lu, Jianhua Hao, Lihua Li   +9 more
wiley   +1 more source

An Algorithm for Automated Measurement of Kinetic Tremor Magnitude Using Digital Spiral Drawings

Digital Biomarkers
Introduction: Essential tremor is a common movement disorder. Numerous validated clinical rating scales exist to quantify essential tremor severity by employing rater-dependent visual observation but have limitations, including the need for trained human
Katherine Longardner, Qian Shen, Bin Tang, Brenton A. Wright, Prantik Kundu, Fatta B. Nahab   +5 more
doaj   +1 more source

Bimanual instrument suturing technique for periodontal and implant microsurgery: A technical note

Clinical Advances in Periodontics, EarlyView.
Abstract Background In the traditional suturing technique, the dominant hand (DH) holds a needle holder, and the non‐dominant hand (NH) performs manual ties without the aid of an instrument. In periodontal and implant microsurgery, finer sutures and needles, e.g., 7‐0 in International Organization for Standardization units, are used, which could be ...
Mark Gordon, Yu‐Chang Wu, Edward Shih‐Chang Tseng, Wen‐Xiang Zhang, Diego Velasquez‐Plata, Hsun‐Liang Chan   +5 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

An optimizing microseismic method for rock burst early warning based on mining production process

Deep Underground Science and Engineering, EarlyView.
A classification early warning method of rock burst based on hourly microseismic data is proposed, which can be combined with the on‐site production process to provide more timely warning. Abstract Microseismic (MS) events have been reported in nearly every coal mining country, which could well lead to rock burst in underground coal mines.
Zepeng Han, Linming Dou, Wu Cai, Mingbo Chi, Guojun Xi, Shuai Chen, Biao Jiao   +6 more
wiley   +1 more source