Results 11 to 20 of about 13,020 (271)

tRNA-derived fragments (tRFs) in cancer

Journal of Cell Communication and Signaling, 2022
tRNA fragments (tRNA derived fragments or tRFs) are small single stranded RNA molecules derived from pre-tRNAs and mature tRNAs. tRFs have been known for a number of years, but previously they were believed to be not important products of tRNA degradation. tRFs can be unique, like tRF-1 s, or redundant, like tRF-3 s and tRF-5 s.
Carlo M Croce, Yuri Pekarsky, Veronica Balatti   +2 more
exaly   +4 more sources

mt tRFs, New Players in MELAS Disease [PDF]

Frontiers in Physiology, 2022
MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is an OXPHOS disease mostly caused by the m.3243A>G mutation in the mitochondrial tRNALeu(UUR) gene.
Salvador Meseguer, M. Rubio
semanticscholar   +5 more sources

Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]

Genomics & Informatics, 2015
tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu, Inhan Lee, Yong Sun Lee, Xiaoyong Bao   +3 more
doaj   +2 more sources

tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers

Nucleic Acids Research, 2016
tRNA-derived small RNA fragments (tRFs) are one class of small non-coding RNAs derived from transfer RNAs (tRNAs). tRFs play important roles in cellular processes and are involved in multiple cancers.
Junhao Li, Lingling Zheng, Liang-Hu Qu   +2 more
exaly   +2 more sources

Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]

Cells
Transfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan, Yan X. Lin, Adesupo A. Adetowubo, Fatmanur Kiliç, Sai Anusha Jonnalagadda, Andrey Grigoriev   +5 more
doaj   +2 more sources

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

Genes and Development, 2009
New types of small RNAs distinct from microRNAs (miRNAs) are progressively being discovered in various organisms. In order to discover such novel small RNAs, a library of 17- to 26-base-long RNAs was created from prostate cancer cell lines and sequenced ...
Yong Sun Lee, Ankit Malhotra, Anindya Dutta   +2 more
exaly   +2 more sources

Differentially expressed tRFs in CD5 positive relapsed & refractory diffuse large B cell lymphoma and the bioinformatic analysis for their potential clinical use

Biology Direct, 2019
Background Patients diagnosed as diffuse large B cell lymphoma (DLBCL) with CD5 positive normally have a worse outcome and poorly respond to the regulatory treatment strategy.
Qingyuan Qu, Ying Li, Xiaosheng Fang, Lingyan Zhang, Chao Xue, Xueling Ge, Xin Wang, Yujie Jiang   +7 more
doaj   +2 more sources

Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases [PDF]

Journal of Translational Medicine
Background Colorectal liver metastases (CRLM) are the leading cause of colorectal cancer (CRC)-related mortality. Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNAs (sncRNA), regulate gene expression, stress response, and ...
Rebecca Zirnbauer, Daphni Ammon, Annalena Renner, Noam Hartman, Polina Kalinina, Patrick Starlinger, Stefan Stremitzer, Christoph Schwarz, Klaus Kaczirek, Michael Bergmann, Dietmar Pils, Johannes Laengle   +11 more
doaj   +2 more sources

Regulatory Roles of Mitochondrial tRNA–Derived Fragments in Cardiovascular Health and Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Mitochondrial tRNA–derived RNA fragments (mt‐tRFs) are small noncoding RNAs generated through specific cleavage. Once considered degradation products, mt‐tRFs are now recognized as bioactive regulatory molecules with critical roles in physiological and ...
Yang Zeng, Qi‐Lan Jiang, Jun Jiang
doaj   +2 more sources

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

Molecular Therapy, 2013
The discovery of small noncoding RNAs (sncRNAs) with regulatory functions is a recent breakthrough in biology. Among sncRNAs, microRNA (miRNA), derived from host or virus, has emerged as elements with high importance in control of viral replication and ...
Yong Sun Lee, Xiaoyong Bao, Inhan Lee
exaly   +2 more sources