Results 31 to 40 of about 13,020 (271)
Scientific Reports, 2021 Small RNAs that originate from transfer RNA (tRNA) species, tRNA-derived fragments (tRFs), play diverse biological functions but little is known for their association with aging.
GiWon Shin +5 more
doaj +1 more source
Current Oncology, 2023 Background: tRNA-derived RNA fragments (tRFs) are a novel class of small ncRNA that are derived from precursor or mature tRNAs. Recently, the general relevance of their roles and clinical values in tumorigenesis, metastasis, and recurrence have been ...
Weigang Liu +7 more
doaj +1 more source
Oncology Letters, 2021 Accumulating evidence has indicated that a group of novel molecules, known as transfer RNA (tRNA)-derived fragments (tRFs) and tRNA halves (tiRNAs), which are derived from tRNAs, serve an essential role in numerous types of human disease, in particular ...
Jinhua Zhang +8 more
semanticscholar +1 more source
Biomedicines, 2021 Multiple myeloma (MM) is a hematologic malignancy arising from the clonal proliferation of malignant plasma cells. tRNA-derived RNA fragments (tRFs) constitute a class of small non-coding RNAs, deriving from specific enzymatic cleavage of tRNAs.
Paraskevi Karousi +14 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: As couples struggle with infertility and livestock producers wish to rapidly improve genetic merit in their herd, assisted reproductive technologies (ART) have become increasingly popular in human medicine as well as the livestock industry ...
Anna K. Goldkamp +3 more
doaj +1 more source
tRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma
BMC Bioinformatics, 2021 Background tRNA-derived fragments have been reported to be key regulatory factors in human tumors. However, their roles in the progression of multiple myeloma remain unknown.
Cong Xu +4 more
doaj +1 more source
Toward an Understanding of Extracellular tRNA Biology
Frontiers in Molecular Biosciences, 2021 Extracellular RNAs (exRNAs) including abundant full length tRNAs and tRNA fragments (tRFs) have recently garnered attention as a promising source of biomarkers and a novel mediator in cell-to-cell communication in eukaryotes.
Adrian Gabriel Torres +2 more
doaj +1 more source
Osteoarthritis and Cartilage, 2020 OBJECTIVES: Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their role in post-transcriptional gene regulation in chondrocytes is unknown.
Jonathan A. Green +3 more
semanticscholar +1 more source
Journal of Hematology & Oncology, 2022 tRNA-derived fragments (tRFs) are a class of small RNAs that occur when tRNAs are broken down by enzymes due to stress. Increasing reports have shown that tRFs are associated with multiple physiological and pathological processes, especially in cancers ...
Sicheng Lu +9 more
doaj +1 more source
tRNA-derived RNA fragments in cancer: current status and future perspectives
Journal of Hematology & Oncology, 2020 Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established.
Mengqian Yu +5 more
doaj +1 more source