Results 41 to 50 of about 13,020 (271)

Transforming Growth Factor-β3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats

Frontiers in Pharmacology, 2021
Patients with a skull defect are at risk of developing cerebrospinal fluid leakage and ascending bacterial meningitis at >10% per year. However, treatment with stem cells has brought great hope to large-area cranial defects.
Shiyi Huang, Fenglin Yu, Yating Cheng, Yangfan Li, Yini Chen, Jianzhong Tang, Yu Bei, Qingxia Tang, Yueping Zhao, Yadong Huang, Yadong Huang, Qi Xiang, Qi Xiang   +12 more
doaj   +1 more source

Parent tRNA Modification Status Determines the Induction of Functional tRNA-Derived RNA by Respiratory Syncytial Virus Infection

Viruses, 2022
tRNA-derived RNA fragments (tRFs) are a recently discovered family of small noncoding RNAs (sncRNAs). We previously reported that respiratory syncytial virus (RSV) infection induces functional tRFs, which are derived from a limited subset of parent tRNAs,
Eun-Jin Choi, Wenzhe Wu, Ke Zhang, Xiaohong Yuan, Junfang Deng, Deena Ismail, Darby L. Buck, Kerrie S. Thomason, Roberto P. Garofalo, Shenglong Zhang, Xiaoyong Bao   +10 more
doaj   +1 more source

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

RNA: A publication of the RNA Society, 2018
tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are abundant small RNAs reported to be associated with Argonaute proteins, yet their function is unclear.
Canan Kuscu, Pankaj Kumar, Manjari Kiran, Zhangli Su, Asrar A. Malik, Anindya Dutta   +5 more
semanticscholar   +1 more source

Telomere Restriction Fragment (TRF) Analysis [PDF]

BIO-PROTOCOL, 2015
While telomerase is expressed in ~90% of primary human tumors, most somatic tissue cells except transiently proliferating stem-like cells do not have detectable telomerase activity (Shay and Wright, 1996; Shay and Wright, 2001). Telomeres progressively shorten with each cell division in normal cells, including proliferating stem-like cells, due to the ...
ilgen Mender, Jerry Shay
openaire   +3 more sources

Plasma tRNA Fragments Derived from 5′ Ends as Novel Diagnostic Biomarkers for Early-Stage Breast Cancer

Molecular Therapy: Nucleic Acids, 2020
Small RNAs derived from tRNAs are attracting considerable attention; however, the effects of tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) as biomarkers have not been investigated in early-stage breast cancer (EBC).
Jingyi Wang, Ge Ma, Minghui Li, Xu Han, Jin Xu, Mengdi Liang, Xinrui Mao, Xiang Chen, Tiansong Xia, Xiaoan Liu, Shui Wang   +10 more
doaj   +1 more source

Comprehensive annotation and characterization of planarian tRNA and tRNA-derived fragments (tRFs)

bioRxiv, 2020
tRNA-derived fragments (tRFs) have recently gained a lot of scientific interest due to their diverse regulatory roles in several cellular processes.
Vairavan Lakshmanan, S. T. N., Dhiru Bansal, Shivaprasad V Padubidri, Dasaradhi Palakodeti, Srikar Krishna   +5 more
semanticscholar   +1 more source

Mitochondrial tRNA-Derived Fragments and Their Contribution to Gene Expression Regulation

Frontiers in Physiology, 2021
Mutations in human mitochondrial tRNAs (mt-tRNAs) are responsible for several and sometimes severe clinical phenotypes, classified among mitochondrial diseases.
Athanasios-Nasir Shaukat, Eleni G. Kaliatsi, Vassiliki Stamatopoulou, Constantinos Stathopoulos   +3 more
doaj   +1 more source

tRNA derived fragments:A novel player in gene regulation and applications in cancer

Frontiers in Oncology, 2023
The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcriptional regulation ...
Shuangshuang Zhang, Shuangshuang Zhang, Xiuchong Yu, Yaoyao Xie, Guoliang Ye, Guoliang Ye, Junming Guo, Junming Guo, Junming Guo   +8 more
doaj   +1 more source

Role of tRNA derived fragments in renal ischemia–reperfusion injury

Renal Failure, 2022
Background Ischemia–reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI). tRNA derived fragments (tRFs/tiRNAs) are groups of small noncoding RNAs derived from tRNAs.
Dan Li, Hao Zhang, Xueqin Wu, Qing Dai, Shiqi Tang, Yan Liu, Shikun Yang, Wei Zhang   +7 more
doaj   +1 more source

Differentially expressed tRNA-derived fragments and their roles in primary cardiomyocytes stimulated by high glucose

Frontiers in Endocrinology, 2023
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus that can cause malignant arrhythmia and sudden death and is associated with cardiomyocyte dysfunction induced by hyperglycemia.
Yongting Zhao, Ruxin Wang, Qi Qin, Jiaojiao Yu, Hui Che, Lihong Wang, Lihong Wang   +6 more
doaj   +1 more source