Results 21 to 30 of about 13,020 (271)

Dysregulated tRNA-derived fragments impair fatty acid metabolism in intrahepatic cholestasis of pregnancy [PDF]

Frontiers in Medicine
ObjectiveIntrahepatic cholestasis of pregnancy (ICP) is a common obstetric complication that occurs predominantly in the mid-to-late gestational period, but its exact etiology remains unclear.
Lian Yang, Xia Yu, Shimao Zhang, Jinzhu Fu, Mengjun Luo, Wei Shen, Cheng Huang, Xiao Yang, Xiao Yang   +8 more
doaj   +2 more sources

Same Fragments, Different Diseases: Analysis of Identical tRNA Fragments Across Diseases Utilizing Functional and Abundance-Based Databases [PDF]

Non-Coding RNA
Background/Objectives: Transfer RNA-derived fragments (tRFs) are small non-coding RNAs increasingly implicated in gene regulation and disease, yet their target specificity and disease relevance remain poorly understood.
Adesupo Adetowubo, Sathyanarayanan Vaidhyanathan, Andrey Grigoriev   +2 more
doaj   +2 more sources

Screening and Comprehensive Analysis of Cancer-Associated tRNA-Derived Fragments

Frontiers in Genetics, 2022
tRNA-derived fragments (tRFs) constitute a novel class of small non-coding RNA cleaved from tRNAs. In recent years, researches have shown the regulatory roles of a few tRFs in cancers, illuminating a new direction for tRF-centric cancer researches ...
Yiran Zhou, Yiran Zhou, Qinghua Cui, Qinghua Cui, Yuan Zhou, Yuan Zhou   +5 more
doaj   +1 more source

Quantitative and qualitative detection of tRNAs, tRNA halves and tRFs in human cancer samples: molecular grounds for biomarker development and clinical perspectives.

Gene, 2023
Transfer RNAs (tRNAs) are small non-coding RNAs playing a central role during protein synthesis. Besides translation, growing evidence suggests that in many contexts, precursor or mature tRNAs can also be processed into smaller fragments playing many non-
Chiara Cabrelle, Federico Manuel Giorgi, D. Mercatelli   +2 more
semanticscholar   +1 more source

tRNA derived small RNAs—Small players with big roles

Frontiers in Genetics, 2022
In the past 2 decades, small non-coding RNAs derived from tRNA (tsRNAs or tRNA derived fragments; tRFs) have emerged as new powerful players in the field of small RNA mediated regulation of gene expression, translation, and epigenetic control.
Suja George, Mohammed Rafi, Maitha Aldarmaki, Mohamed ElSiddig, Mariam Al Nuaimi, Khaled M. A. Amiri, Khaled M. A. Amiri   +6 more
doaj   +1 more source

tRNA-derived fragments from wheat are potentially involved in susceptibility to Fusarium head blight

BMC Plant Biology, 2022
Background Fusarium head blight (FHB) caused by Fusarium graminearum is a devastating fungal disease of wheat. The mechanism underlying F. graminearum-wheat interaction remains largely unknown. tRNA-derived fragments (tRFs) are RNase-dependent small RNAs
Zhengxi Sun, Yi Hu, Yilei Zhou, Ning Jiang, Sijia Hu, Lei Li, Tao Li   +6 more
doaj   +1 more source

Emerging roles of tRNA-derived fragments in cancer

Molecular Cancer, 2023
tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of ...
Min Fu, Jianmei Gu, Maoye Wang, Jiahui Zhang, Yanke Chen, Pengcheng Jiang, Taofeng Zhu, Xu Zhang   +7 more
doaj   +1 more source

tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation

Frontiers in Genetics, 2020
tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life.
Anahi Molla-Herman, Margarita T. Angelova, Maud Ginestet, Clément Carré, Christophe Antoniewski, Jean-René Huynh   +5 more
doaj   +1 more source

Identification of tRNA-Related Fragments and Their Potential Regulatory Effects in Thyroid-Associated Ophthalmopathy

Frontiers in Genetics, 2022
Recently, the potential role of tRNA-related fragments (tRFs) in ophthalmic diseases has been extensively researched. However, systematic studies on the potential regulatory effects of tRFs in thyroid-associated ophthalmopathy (TAO) are lacking.
Zifan Yue, Fei Tong, Chengcheng Zeng, Ruili Wei   +3 more
doaj   +1 more source

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Frontiers in Cell and Developmental Biology, 2021
Ultraviolet (UV) radiation is a major environmental factor contributing skin damage. As UV exposure is inevitable, it is necessary to pay attention to the underlying molecular mechanisms of UV-induced skin damage to develop effective therapies.
Yuan Fang, Yang Liu, Yu Yan, Yiyu Shen, Zenan Li, Xu Li, Yufang Zhang, Zhigang Xue, C. Peng, Xiang Chen, K. Cao, Jianda Zhou   +11 more
semanticscholar   +1 more source