Results 21 to 30 of about 35,982 (245)

Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis [PDF]

Journal of Biological Chemistry, 2000
The perilipins are the most abundant proteins at the surfaces of lipid droplets in adipocytes and are also found in steroidogenic cells. To investigate perilipin function, perilipin A, the predominant isoform, was ectopically expressed in fibroblastic 3T3-L1 pre-adipocytes that normally lack the perilipins.
D L, Brasaemle, B, Rubin, I A, Harten, J, Gruia-Gray, A R, Kimmel, C, Londos   +5 more
openaire   +2 more sources

Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver

Journal of Lipid Research, 2012
Intrahepatic lipid accumulation is extremely common in obese subjects and is associated with the development of insulin resistance and diabetes. Hepatic diacylglycerol and triacylglycerol synthesis predominantly occurs through acylation of glycerol-3 ...
Angela M. Hall, Kou Kou, Zhouji Chen, Terri A. Pietka, Mrudula Kumar, Kevin M. Korenblat, Kyuha Lee, Kay Ahn, Elisa Fabbrini, Samuel Klein, Bryan Goodwin, Brian N. Finck   +11 more
doaj   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Circulating lipids in men with type 2 diabetes following 3 days on a carbohydrate‐free diet versus 3 days of fasting

Physiological Reports, 2020
Objective We have been interested in determining the effects of dietary changes on fuel metabolism and regulation in men with type 2 diabetes mellitus (T2DM).
Frank Q. Nuttall, Rami M. Almokayyad, Mary C. Gannon   +2 more
doaj   +1 more source

Chloroplasts Isolation from Chlamydomonas reinhardtii under Nitrogen Stress

Frontiers in Plant Science, 2017
Triacylglycerols are produced in abundance through chloroplast and endoplasmic reticulum pathways in some microalgae exposed to stress, though the relative contribution of either pathway remains elusive.
Miao Yang, Miao Yang, Miao Yang, Jun-Peng Jiang, Jun-Peng Jiang, Xi Xie, Ya-Dong Chu, Yan Fan, Yan Fan, Xu-Peng Cao, Song Xue, Zhan-You Chi   +11 more
doaj   +1 more source

Differential Mobilization of the Phospholipid and Triacylglycerol Pools of Arachidonic Acid in Murine Macrophages

Biomolecules, 2022
Innate immune cells such as monocytes and macrophages contain high levels of arachidonic acid (AA), part of which can be mobilized during cellular activation for the formation of a vast array of bioactive oxygenated metabolites. Monocytes and macrophages
Miguel A. Bermúdez, Julio M. Rubio, María A. Balboa, Jesús Balsinde   +3 more
doaj   +1 more source

Flagella-Associated WDR-Containing Protein CrFAP89 Regulates Growth and Lipid Accumulation in Chlamydomonas reinhardtii

Frontiers in Plant Science, 2018
WD40-repeat (WDR) domain-containing proteins are subunits of multi-protein E3 ligase complexes regulating various cellular and developmental activities in eukaryotes.
Qiulan Luo, Qiulan Luo, Qiulan Luo, Wenwen Song, Yajun Li, Chaogang Wang, Chaogang Wang, Zhangli Hu, Zhangli Hu   +8 more
doaj   +1 more source

Towards oilcane: Engineering hyperaccumulation of triacylglycerol into sugarcane stems

GCB Bioenergy, 2020
Metabolic engineering to divert carbon flux from sucrose to oil in high biomass crop like sugarcane is an emerging strategy to boost lipid yields per hectare for biodiesel production.
Saroj Parajuli, Baskaran Kannan, Ratna Karan, Georgina Sanahuja, Hui Liu, Eva Garcia‐Ruiz, Deepak Kumar, Vijay Singh, Huimin Zhao, Stephen Long, John Shanklin, Fredy Altpeter   +11 more
doaj   +1 more source

Citrate-Mediated Acyl-CoA Synthesis Is Required for the Promotion of Growth and Triacylglycerol Production in Oleaginous Yeast Lipomyces starkeyi

Microorganisms, 2021
The oleaginous yeast Lipomyces starkeyi is an excellent producer of triacylglycerol (TAG) as a feedstock for biodiesel production. To understand the regulation of TAG synthesis, we attempted to isolate mutants with decreased lipid productivity and ...
Rikako Sato, Satoshi Ara, Harutake Yamazaki, Koji Ishiya, Sachiyo Aburatani, Hiroaki Takaku   +5 more
doaj   +1 more source