Results 41 to 50 of about 47,218 (310)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Effects of Opuntia stricta var. dillenii Extracts Obtained from Prickly Pear and an Industrial By-Product on Maturing Pre-Adipocytes

Plants
Opuntia stricta var. dillenii, a member of the Cactaceae family, produces a fruit known as prickly pear. This fruit is rich in bioactive compounds, including betalains and phenolic compounds, which play an important role in health promotion due to their ...
Iván Gómez-López, Itziar Eseberri, Stéphanie Krisa, M. Pilar Cano, María P. Portillo   +4 more
doaj   +1 more source

A Synergistic Genetic Engineering Strategy Induced Triacylglycerol Accumulation in Potato (Solanum tuberosum) Leaf

Frontiers in Plant Science, 2020
Potato is the 4th largest staple food in the world currently. As a high biomass crop, potato harbors excellent potential to produce energy-rich compounds such as triacylglycerol as a valuable co-product. We have previously reported that transgenic potato
Xiao-yu Xu, Xiao-yu Xu, Sehrish Akbar, Pushkar Shrestha, Lauren Venugoban, Rosangela Devilla, Dawar Hussain, Jiwon Lee, Melanie Rug, Lijun Tian, Thomas Vanhercke, Surinder P. Singh, Zhongyi Li, Peter J. Sharp, Qing Liu   +14 more
doaj   +1 more source

Human Brain Lipidomics: Investigation of Formalin Fixed Brains

Frontiers in Molecular Neuroscience, 2022
Human brain lipidomics have elucidated structural lipids and lipid signal transduction pathways in neurologic diseases. Such studies have traditionally sourced tissue exclusively from brain bank biorepositories, however, limited inventories signal that ...
Aaron W. Beger, Kathleen A. Hauther, Beatrix Dudzik, Randall L. Woltjer, Randall L. Woltjer, Paul L. Wood   +5 more
doaj   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

Journal of Lipid Research, 2011
Acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) is thought to be crucial for dietary fat absorption. Indeed, mice lacking the enzyme (Mogat2−/−) are resistant to obesity and other metabolic disorders induced by high-fat feeding.
David W. Nelson, Yu Gao, Nicole M. Spencer, Taylor Banh, Chi-Liang Eric Yen   +4 more
doaj   +1 more source

Higher Genetically Predicted Triglycerides, LDL, and HDL Increase the Vitamin D Deficiency: A Mendelian Randomization Study

Frontiers in Nutrition, 2022
IntroductionIt has been proven that high body mass index (BMI) levels can cause vitamin D deficiency, but the mechanism is still unclear. Therefore, this study attempts to explain this phenomenon from the perspective of blood lipid by using mendelian ...
Zhe Lu, Yang Jiao, Jun Li
doaj   +1 more source

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

, 2008
BackgroundTuberculous sputum provides a sample of bacilli that must be eliminated by chemotherapy and that may go on to transmit infection. A preliminary observation that Mycobacterium tuberculosis cells contain triacylglycerol lipid bodies in sputum ...
Richard A. Adegbola (20657), Su-Min Lee, Rebecca J Smith, Richard A Adegbola (16048106), Anna L Sherratt (16048100), Lee Su-Min, Jason Hinds (41307), Sherratt, AL, Natalie J Garton (9382763), Anna L. Sherratt (7584722), Michael R. Barer (7582793), Simon J Waddell, Claire Senner, Simon J. Waddell (7584719), Michael R Barer (8880551), Smith Rebecca J, Philip D Butcher (16047203), Rajakumar, K, Gurdyal S Besra (8348871), Waddell, SJ, Senner Claire, Besra, GS, Simon Waddell (4462816), Philip D. Butcher (7584725), Philip D Butcher, Sherratt Anna L, Smith, RJ, Garton Natalie J, Hinds, J, Su-Min Lee (44403), Gurdyal S. Besra (37660), Waddell Simon J, Jason Hinds, Garton, NJ, Barer Michael R, Butcher, PD, Natalie J. Garton (7129730), Besra, Gurdyal; id_orcid, Barer, MR, Besra Gurdyal S, Kumar Rajakumar, Rajakumar Kumar, Natalie J Garton, Richard A Adegbola, Hinds Jason, Gurdyal S Besra, Michael R Barer, Rebecca J. Smith (2526727), Rebecca J Smith (16048103), Anna L Sherratt, Lee, SM, Lee, S-M, Kumar Rajakumar (6761), Adegbola Richard A, Butcher Philip D, Adegbola, RA, Claire Senner (44405), Senner, C   +57 more
core   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia

Journal of Lipid Research, 2010
We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-
Meenakshi Sundaram, Shumei Zhong, Maroun Bou Khalil, Hu Zhou, Zhenghui G. Jiang, Yang Zhao, Jahangir Iqbal, M. Mahmood Hussain, Daniel Figeys, Yuwei Wang, Zemin Yao   +10 more
doaj   +1 more source