Neue Triazol‐ und Triazinderivate [PDF]
Berichte der deutschen chemischen Gesellschaft, 1893 n ...
openaire +3 more sources
Syntheses, Antibacterial and Antifungal Activities of Substituted-Thiazolo-1,3,4-Thiadiazoles, 1,3,4-Oxadiazoles and 1,2,4-Thiazoles [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1998 Starting from readily available 2-substituted-4-methylthiazole-5-carboxylic acid hydrazide (1), The title compounds were prepared. The reaction of compound 1 (R=CH3) with formic acid yielded 1-(formyl)-2-(2,4-dimethylthiazole-5-carboxyl) hydrazine (2 ...
Abbas Shafiee +2 more
doaj
New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2
Molecules, 2019 The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT ...
Rania Hamdy +4 more
doaj +1 more source
Probing the fluctuating magnetic field of Fe-triazole spin-crossover thin-layers with nitrogen-vacancy centers in diamond [PDF]
Fe$^{\mathrm{II}}$ spin-crossover (SCO) complexes are materials that change their magnetic properties upon temperature variation, exhibiting a thermal hysteresis. Particularly interesting for magnetic-memory applications are thin layers of SCO complexes, where practical magnetic probing techniques are required.
arxiv +1 more source
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 [PDF]
, 2011 We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays.
Agnew, Heather D. +12 more
core +2 more sources
Triazole Fungicides Can Induce Cross-Resistance to Medical Triazoles in Aspergillus fumigatus
PLoS ONE, 2012 Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, an environmental route of resistance development has been suggested through exposure to 14α-demethylase inhibitors (DMIs).
Snelders, E. +9 more
openaire +8 more sources
Angewandte Chemie, EarlyView.Die Erzeugung funktionalisierter Ubiquitinbausteine mittels Expression in E. coli bietet Zugang zu verschiedenen Di‐, Tri‐ und Tetra‐Ubiquitinketten. Photoinitiierte Thiol‐En‐Klickreaktionen werden dabei in Kombination mit einer Maskierungs‐ und Schutzgruppenstrategie zum kontrollierten Aufbau von Ubiquitinketten sowie zur Semisynthese von ...
Moritz Urschbach +6 more
wiley +1 more source
Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad +4 more
core +1 more source
Tailoring the Hydrophobicity of Mesoporous Organosilica for Protein Trapping and Supported Catalysis [PDF]
arXiv, 2019 We propose a method to enhance lysozyme trapping and supported-Copper catalysis when confined in organosilica materials. The direct synthesis presented here allows the control of the silica surface hydrophobicity by uniform introduction of methyl or phenyl groups.
arxiv
Analyzing the Binding of Co(II)-specific Inhibitors to the Methionyl Aminopeptidases from \u3cem\u3eEscherichia coli\u3c/em\u3e and \u3cem\u3ePyrococcus furiosus\u3c/em\u3e [PDF]
, 2009 Methionine aminopeptidases (MetAPs) represent a unique class of protease that is capable of the hydrolytic removal of an N-terminal methionine residue from nascent polypeptide chains.
Bennett, Brian +4 more
core +2 more sources