Results 141 to 150 of about 178,442 (380)
Advanced Synthesis &Catalysis, EarlyView.A mild, scalable electrocatalytic method for direct lactonization of benzylic alcohols to phthalides using N‐hydroxyphthalimide as a redox mediator is reported. This metal‐free process proceeds via a phthalimide‐N‐oxyl‐mediated hydrogen atom transfer mechanism, shows broad scope with good to excellent yields, and enables late‐stage functionalizations ...
Pietro Ronco +6 more
wiley +1 more source
1-[(1-Benzyl-1H-1,2,3-triazol-4-yl)methyl]-1H-1,3-benzodiazole
IUCrData, 2017 The title molecule, C17H15N5, adopts a Z-shaped conformation, with the benzyl and benzodiazole substituents disposed on opposite sides of the plane of the triazole ring.
Azzeddine Sahbi +5 more
doaj +1 more source
Advanced Synthesis &Catalysis, EarlyView.Unleashing the power of Ag(I)‐acetylides with LiCl/dimethyl sulfoxide (DMSO). The LiCl/DMSO mixture have an unexplored ability to dramatically increase the solubility of Ag(I)‐acetylides regardless of their molecular structure, which is explored to achieve high chemoselectivity in the Cu(I)‐catalyzed interrupted cycloaddition between organic azides, Ag(
Diego Seckler +8 more
wiley +1 more source
New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2
Molecules, 2019 The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT ...
Rania Hamdy +4 more
doaj +1 more source
Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey [PDF]
, 2009 With the goal of identifying alkyne-like reagents for use in click chemistry, but without Cu catalysts, we used B3LYP density function theory (DFT) to investigate the trends in activation barriers for the 1,3-dipolar cycloadditions of azides with various
Chenoweth, David +2 more
core +1 more source
Synthesis and evaluation of a novel fluorescent sensor based on hexahomotrioxacalix[3]arene for Zn²+ and Cd²+ [PDF]
, 2016 A novel type of selective and sensitive fluorescent sensor having triazole rings as the binding sites on the lower rim of a hexahomotrioxacalix[3]arene scaffold in a cone conformation is reported.
Ikejiri, Yusuke +8 more
core +1 more source
A Polyoxometalate—Carbon Nanotube Enhanced Electrochemical Sensor for Aptamer‐Based Diagnostics
Advanced Sensor Research, EarlyView.The high electroactive surface area of multi‐walled carbon nanotubes decorated with aptamer‐functionalized polyoxovanadate units enables a ≈1000‐fold increase in peak current response for a model diclofenac detection in aqueous solution compared to unmodified platinum microelectrodes.
Eric Vogelsberg +2 more
wiley +1 more source
Electroactive tetrathiafulvalene based pyridine-mono and -bis(1,2,3-triazoles) click ligands: synthesis, crystal structures and coordination chemistry [PDF]
, 2014 Electroactive ligands picoline-1,2,3-triazole-5-DM-TTF and lutidine-bis(1,2,3-triazole-5-DM-TTF) are synthesized by click chemistry following the ruthenium catalyzed azide–alkyne cycloaddition strategy.
N. Avarvari, T. Biet
core +3 more sources
Global targeting of functional tyrosines using sulfur triazole exchange chemistry
Nature Chemical Biology, 2019 Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g., cysteine and lysine), a large fraction of the ...
H. S. Hahm +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang +7 more
wiley +1 more source