Results 141 to 150 of about 46,961 (245)

Concurrent Administration of Triazoles with Chemotherapeutic and/or Immunosuppressant Agents Known to Have Moderate-to-Severe Drug-Drug Interactions in Patients with Hematologic Malignancies Hospitalized for Invasive Aspergillosis. [PDF]

Mycopathologia
Walsh TJ, Coleman CI, Johnson MD, Lovelace B, Alexander BD.   +4 more
europepmc   +1 more source

Development of a Self‐Adjuvanting Influenza Peptide–Glycolipid Conjugate Inducing CD8+ T‐Cell Immunity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi, Hideki Ogura, Takanori Matsumaru, Satoshi Ishido, Yukari Fujimoto   +4 more
wiley   +1 more source

Design, synthesis, structural characterization, anticancer evaluation, and computational studies of novel quinoline-1,2,3-triazole glycohybrids. [PDF]

RSC Adv
Kumar R, Chauhan D, Gupta RK, Dubey PK, Kushwaha D.   +4 more
europepmc   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Cone <i>p</i>-aminocalix[4]arenes enriched with 'clickable' alkyne or azide functionalities. [PDF]

Beilstein J Org Chem
Korniltsev I, Bazhenov V, Gorbunov A, Cheshkov D, Bezzubov S, Kovalev V, Vatsouro I.   +6 more
europepmc   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Efficient synthesis, dual anti-tubercular and antioxidant activity of triazole-acetophenone derivatives: enhanced efficacy <i>via</i> esterification and quantum mechanical validation of CYP121 binding. [PDF]

RSC Adv
Jagtap RA, Jagdale BS, Dhonnar SL, Shaikh SA, More RA, Alavala RR, Muteeb G, Fernandez-Conde D, Pawar TJ, Meshram RJ, Escobar-Cabrera J, Chobe SS.   +11 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Acetylcholinesterase and β-Secretase 1 Inhibitors. [PDF]

Int J Mol Sci
Drozdowska D, Pawelski D, Wróbel-Tałałaj A, Plonska-Brzezinska M, Kolesinska B, Lazny R, Seroka B, Parzych C, Ratkiewicz A.   +8 more
europepmc   +1 more source

DksA inhibitors against intracellular and persistent <i>Salmonella</i> are effective in acute models of infection. [PDF]

Sci Adv
Kim JS, Kumar V, Liu L, Choi YJ, Senovaityte S, McCollister BD, Wlodarchak N, Orlicky DJ, Rice PJ, Dai S, Wempe MF, Vázquez-Torres A.   +11 more
europepmc   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source