Results 141 to 150 of about 123,319 (291)

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Enhanced proton conductivity in azole-functionalized three-dimensional crystalline covalent organic frameworks. [PDF]

Nat Commun
Yao A, Zhu C, Liu J, Xu H, Shao K, Sun C, Qin C, Wang X, Zang H, Su Z, Jiang D.   +10 more
europepmc   +1 more source

Data for "Probing the fluctuating magnetic field of Fe-triazole spin-crossover thin-layers with nitrogen-vacancy centers in diamond" [PDF]

Isabel Cardoso Barbosa, Tim Hochdörffer, Juliusz A. Wolny, Dennis Lönard, Stefan Johansson, Jonas Gutsche, Volker Schünemann, Artur Widera   +7 more
openalex   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Persistence of triazole fungicides in agricultural topsoil is driven by reduced bioaccessibility with aging. [PDF]

J Environ Qual
Johnsen AR, Albers CN, Badawi N, Bollmann UE.   +3 more
europepmc   +1 more source

C(5)—H arylation of 1-substituted 1,2,4-triazoles with aryl halides under Pd/NHC catalysis [PDF]

Alexander V. Astakhov, Andrey Yu. Chernenko, Vadim V. Kutyrev, Victor M. Chernyshev   +3 more
openalex   +1 more source

New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking

, 2021
Ashruba B. Danne, Mukund V. Deshpande, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Bapurao B. Shingate   +4 more
openalex   +1 more source

Characteristics of fungicide resistance in Asian soybean rust (Phakopsora pachyrhizi) in Paraguay for 2022–2023: insights from genetic mutations and molecular dynamics simulations

Pest Management Science, EarlyView.
Phakopsora pachyrhizi in Paraguay showed diverse resistance to DMI, SDHI, and QoI fungicides at both regional and intra‐field levels, likely driven by target mutation genes. Abstract BACKGROUND Phakopsora pachyrhizi, the causative agent of Asian soybean rust, poses a major threat to soybean production in South America. The rising incidence of fungicide
Ryusuke Hagihara, Ryo Okada, Takuya Hayashi, Hideaki Tateishi, Wilfrido Morel, Naoki Yamanaka   +5 more
wiley   +1 more source

Metal-based triazoles as a medical marvel of the modern era: a comprehensive review. [PDF]

RSC Adv
Haseeb K, Mustafa MH, Zafar W, Hassan AU, Chohan ZH, Sumrra SH.   +5 more
europepmc   +1 more source