Results 151 to 160 of about 178,442 (380)

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]

, 2010
The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr, Bock, David J. Stephens, Derby, Doherty, Erickson, Falnes, Feng, Feng, Fiebiger, Frédéric Boal, Fuchs, Gewald, Girod, Guetzoyan, Guy J. Clarkson, Helms, Herold, Hey, Hill, J. Michael Lord, Jackson, Johannes, Johannes, Johannes, Klausner, Lieu, Linstedt, Lu, Lucie J. Guetzoyan, Lynne M. Roberts, Macia, McKenzie, Monier, Nambiar, Nieland, Pavelka, Pelish, Perez-Victoria, Peyroche, Pirali, Plourde, Ponnambalam, Renault, Robert A. Spooner, Rostovtsev, Saenz, Saenz, Sandvig, Shima, Shin, Shin, Spooner, Spooner, Stechmann, Tai, Tsai, Viaud, Volpicelli-Daley, Wells, White, Wilcke, Yarrow, Yoshino, Zeghouf, Zhang, Zhao, Zolov   +67 more
core   +1 more source

Triazole aus Dibenzamid, beziehungsweise Diparatoluylamid und Hydrazinsalzen [PDF]

, 1916
Herbert Wolchowe
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Cupin‐Type Dimethylsulfoniopropionate Lyase from Pelagibacter ubique (DddKPu) Catalyzes Aza‐Michael Addition of Primary and Secondary Amines to Acrylic Acid

Angewandte Chemie, EarlyView.
A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri, Angela Mourelle, Teodor Parella, Jordi Bujons, Carlos J. Moreno, Pere Clapés   +5 more
wiley   +2 more sources

9-Ethyl-6-methyl-7H-1,2,4-triazolo[4,3-b][1,2,4]triazepin-8(9H)-one

IUCrData, 2016
In the title compound, C8H11N5O, the triazepine ring displays a boat conformation. Its mean plane is inclined to the triazole ring by 22.10 (9)°. In the crystal, molecules are linked by C—H...O hydrogen bonds to form chains parallel to the b-axis ...
Youness El Bakri, Abdallah Harmaoui, El Mokhtar Essassi, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Recent developments on triazole nucleus in anticonvulsant compounds: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Epilepsy is one of the common diseases seriously threatening life and health of human. More than 50 million people are suffering from this condition and anticonvulsant agents are the main treatment.
Ming‐Xia Song, Xianqing Deng
semanticscholar   +1 more source

Beyond Density: Unveiling the Trade‐Off in Catalytic Site Optimization Using Defect‐Engineered UiO‐66

Advanced Science, EarlyView.
A well‐designed experimental model reveals a trade‐off between intrinsic activity and catalytic site density in performance optimization, due to inherent diffusion resistance arising from substrate adsorption at catalytic sites. Abstract Enhancing intrinsic activity and increasing catalytic site density are two widely employed strategies to improve ...
Guo‐Ying Han, Yi Ji, Xiang‐Yu Li, Yu Gai, Guo‐Zhen Hou, Qin‐Yi Cheng, Zhong Zhang, Yiwei Liu, Jia Wang, Pascal Van Der Voort, Guangjin Hou, Xin‐Ping Wu, Gaohong He, Xiao Feng   +13 more
wiley   +1 more source

The Preparation of Some N-Methyl-1,2,3-Triazoles. [PDF]

, 1959
Christian Pedersen, Anita Lehtinen, S. V. Vardheim, B. Högberg, P. Kneip, H. Palmstierna   +5 more
openalex   +1 more source

Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts

Advanced Science, EarlyView.
The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song, Shiqin Li, Yujuan Luo, Dongxiang Wei, Junmei Shang, Hongyun Wu, Gangqi Fang, Chengshu Wang   +7 more
wiley   +1 more source

MitoSiege‐Driven Catalase Collapse: A GSH‐Responsive, Mitochondria‐Targeted COF Prodrug for Amplified Chemodynamic Therapy

Angewandte Chemie, EarlyView.
The construction of mitochondria‐targeted nanomedicine is achieved by incorporating into COFs a prodrug, which is a catalase inhibitor and a Fenton‐like reaction copper complex linked by a disulfide bond. These findings confer organelle‐specific targeting properties to COF materials for efficient delivery of therapeutic drugs and enhanced cancer ...
Qihang Ding, Bo Wang, Zixuan Zhan, Paramesh Jangili, Junyang Chen, Rakesh Mengji, Hyeonji Rha, Yang Li, Jian Tian, Jong Seung Kim   +9 more
wiley   +2 more sources