Results 11 to 20 of about 123,319 (291)

Versatile Synthetic Platform for 1,2,3-Triazole Chemistry

ACS Omega, 2022
1,2,3-Triazole scaffolds are not obtained in nature, but they are still intensely investigated by synthetic chemists in various fields due to their excellent properties and green synthetic routes.
Disha P. Vala, Ruturajsinh M. Vala, H. Patel   +2 more
semanticscholar   +1 more source

Trends in Agricultural Triazole Fungicide Use in the United States, 1992–2016 and Possible Implications for Antifungal-Resistant Fungi in Human Disease

Environmental Health Perspectives, 2021
Background: The fungus Aspergillus fumigatus (A. fumigatus) is the leading cause of invasive mold infections, which cause severe disease and death in immunocompromised people.
Mitsuru Toda, Karlyn D. Beer, K. Kuivila, T. Chiller, Brendan R. Jackson   +4 more
semanticscholar   +1 more source

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

Journal of chemistry, 2022
A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper.
M. Marzi, M. Farjam, Zahra Kazeminejad, A. Shiroudi, A. Kouhpayeh, E. Zarenezhad   +5 more
semanticscholar   +1 more source

Effects of Triazole Fungicides on Soil Microbiota and on the Activities of Enzymes Found in Soil: A Review

Agriculture, 2021
Triazole fungicides can manifest toxicity to a wide range of non-target organisms. Within this study we present a systematic review of the effects produced on the soil microbiota and activity of soil enzymes by the following triazole fungicides ...
D. Roman, Denisa Ioana Voiculescu, M. Filip, V. Ostafe, A. Isvoran   +4 more
semanticscholar   +1 more source

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Frontiers in Pharmacology, 2021
Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates
T. Liang, Xiangyang Sun, Wenhong Li, G. Hou, F. Gao   +4 more
semanticscholar   +1 more source

Modern approaches to studying the antimicrobial and antifungal activities of new 1,2,4-triazole derivatives

Фармацевтичний журнал, 2022
1,2,4-Triazole and its derivatives are a promising class of organic compounds. For a long time, they remain in the spotlight due to a number of unique properties: high ability to chemical transformations, the presence of various types of biological ...
M. V. Ogloblina, I. V. Bushueva, V. V. Parchenko   +2 more
doaj   +1 more source

Synthesis and Characterization of the Triazole Derived from Thiosemicarbazide, 4-Amino-5-Phenyl-4H-1,2,4- Triazole-3-Thiol and Their Copper(II) and Nickel(II) Complexes [PDF]

Engineering and Technology Journal, 2013
Triazole N-(3-mercapto-5-phenyl-4H-1,2,4-triazol-4-yl)hydrazinecarbothioamide prepared in good yield via the condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and thiosemicarbazide.
Hamdan Abood Aday
doaj   +1 more source

hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

Microbiology Spectrum, 2023
Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat
Ana C. O. Souza, Wenbo Ge, Nathan P. Wiederhold, Jeffrey M. Rybak, Jarrod R. Fortwendel, P. David Rogers   +5 more
doaj   +1 more source

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. We have continued the study of 1,2,4-triazole derivatives, which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus.
Yu. G. Samelyuk , A. G. Kaplaushenko
doaj   +1 more source

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2, 5, 7,
R. Khattab, A. Alshamari, Allam A Hassan, H. Elganzory, W. El‐Sayed, H. Awad, E. Nossier, N. A. Hassan   +7 more
semanticscholar   +1 more source