Results 211 to 220 of about 157,767 (395)

Carbazole Framework as Functional Scaffold for the Design of Synthetic Receptors

open access: yesChemistry – A European Journal, EarlyView.
Carbazole‐based receptors play a crucial role in supramolecular chemistry, due to their unique geometry, photophysical properties, strong hydrogen bonding features, and versatility. This review examines prominent examples, focusing on how structural modifications shape binding affinity and selectivity for various guests, showcasing the potential of ...
Alessio Carioscia   +6 more
wiley   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

open access: yesChemistry – A European Journal, EarlyView.
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi   +8 more
wiley   +1 more source

Click‐Functionalized Cyanine Fluorogenic Dimers for Improved Detection of GPCRs: Application to Imaging of ApelinR in Living Cells

open access: yesChemistry – A European Journal, EarlyView.
A click‐mediated functionalization of a cyanine 5.5 bearing a terminal alkyne gave a rapid access to a library of ten new cyanine dyes and their corresponding dimers. A structure‐interaction relationship study led to the identification of an optimal dimer which was conjugated to the apelin‐17 ligand and enabled imaging of ApelinR under no‐wash ...
Océane Florès   +10 more
wiley   +1 more source

A Mechanochemically Active Metal‐Organic Framework (MOF) Based on Cu‐Bis‐NHC‐Linkers: Synthesis and Mechano‐Catalytic Activation

open access: yesMacromolecular Chemistry and Physics, Volume 224, Issue 1, January 2023., 2023
A Cu(I) bis (NHC) containing metal‐organic framework (MOF) based on ([Zn4O{Cu(L)2}2] is subjected to ultrasonication leading to mechanochemical activation in solution to achieve 26.5% conversion of a Cu‐catalyzed “click” reaction (CuAAC). This approach opens a prospect for stress‐sensing in polymer networks with embedded MOFs.
Kshitij Sanjay Shinde   +3 more
wiley   +1 more source

Exploiting Activated Alkyne Chemistry for the Synthesis of Tailored Amphiphilic Janus Dendrimers with Aggregation‐Induced Emission and Their Assemblies for Cell Imaging

open access: yesChemistry – A European Journal, EarlyView.
Amphiphilic Janus dendrimers (AJDs) synthesized via activated alkyne‐hydroxyl “click” chemistry exhibit aggregation‐induced emission (AIE) properties and self‐assemble into fluorescent nanostructures, including dendrimersomes and micelles. These assemblies, with excellent biocompatibility and efficient cellular uptake, demonstrate potential for live ...
Hossein Rasoulmosaedi   +4 more
wiley   +1 more source

Influence of Protonation and Iron(II) Complexation on Magnetic Interactions in Spin‐Labeled Mechanically Interlocked Molecules

open access: yesChemistry – A European Journal, EarlyView.
The study investigates the influence of protonation and Fe(II) complexation on exchange coupling and magnetic properties in a [2]‐rotaxane and its free‐axle biradicals. Mechanical bonding markedly modifies magnetic interactions, highlighting its potential for enabling the design of interlocked molecules with tunable spin states for advanced ...
Lorenzo Gualandi   +7 more
wiley   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

open access: yesChemistry – A European Journal, Accepted Article.
Mechanochemical synthesis has emerged as a powerful and more sustainable alternative to conventional solution‐based methods, offering advantages such as no or only minimal solvent use, reduced reaction times, and simplified operational conditions.
Michael Schnürch, Nina Biedermann
wiley   +1 more source

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