Results 241 to 250 of about 157,767 (395)

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Moving beyond multi-triazole to multi-fungicide resistance: Broader selection of drug resistance in the human fungal pathogen Aspergillus fumigatus. [PDF]

PLoS Pathog
Kanellopoulos SG, Snelders E.
europepmc   +1 more source

Complexes of 1,2,4-Triazoles, Part XVII The Crystal Structure of Tris-μ-(4-ethyl-1,2,4-triazole-N¹,N²)- (4-ethyl-1,2,4-triazole-N¹)-aquo-bis [bis(thiocyanato-N)- nickel(II)]hydrate, Ni₂(C₄N₃H₇)₄(H₂O)(NCS)₄ ·H₂O(x ≃ 2.5) [PDF]

, 1981
G. Vos, Anthonie J. de Kok, G. C. Verschoor   +2 more
openalex   +1 more source

Improved C5‐Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2‐Deoxy‐2,3‐Didehydro‐N‐Acetyl Neuraminic Acid

ChemMedChem, EarlyView.
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan, Elisa G. Carvajal, Christopher W. Cairo   +2 more
wiley   +1 more source

Activation of Polypropylene (PP) Fiber Surface with 1-Vinyl-1,2,4-triazole and Vinyl Acetate: Synthesis, Characterization, and Application in Cementitious Systems. [PDF]

Materials (Basel)
Kaya Y, Balcı P, Özen S, Mardani A, Kara A.   +4 more
europepmc   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Recent advances in microwave-assisted synthesis of triazoles and their derivatives: a green approach toward sustainable development methods. [PDF]

RSC Adv
Swami S, Sharma N, Sharma G, Shrivastava R.   +3 more
europepmc   +1 more source

Efficacy of 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-carboxamide Against Influenza Virus Infections in Mice

, 1975
Frederick E. Durr, H. F. Lindh, Martin Forbes   +2 more
openalex   +1 more source

Gas phase flash pyrolysis of 3-azido-1,2,4-triazole: generation and ultraviolet photoelectron spectrum of N-cyanomethanimine [PDF]

, 1988
I. B'Shary, C. Guímon, M. GRIMAUD, G. Pfister‐Guillouzo, D. Liotard   +4 more
openalex   +1 more source

35Cl NMR of Metal‐Organic Frameworks: What Can We Learn?

Chemistry–Methods, EarlyView.
35Cl solid‐state NMR of MOFs offers insights into bonding mode and character, hydrogen bonding, phase transitions, and reaction products, even near paramagnetic centers. 35Cl NMR parameters reflect Cl coordination and local geometry. DFT methods accurately predict 35Cl NMR parameters. This 35Cl NMR/DFT approach is applicable to other MOFs and materials.
Wanli Zhang, Bryan E. G. Lucier, Mathew J. Willans, Yining Huang   +3 more
wiley   +1 more source