Results 21 to 30 of about 123,319 (291)

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The aim of study was to investigate diuretic activity of 1,2,4-triazole derivatives which contain С5 atom 5-bromfuran-2-yl substituent in the 1,2,4-triazole nucleus, and to establish interrelation between chemical structure and diuretic action of 1,2,4 ...
Ye. S. Pruglo, A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh   +3 more
doaj   +1 more source

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The resistance of such strains as Staphylococcus aureus, Escherichia coli extends to many antimicrobial drugs. This problem can be solved by searching for new drugs with high bactericidal and antifungal action.
Ye. O. Karpun, N. M. Polishchuk
doaj   +1 more source

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

Molecules, 2021
As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed.
D. Pereira, M. Pinto, M. Correia-da-Silva, H. Cidade   +3 more
semanticscholar   +1 more source

Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative

Journal of International Medical Research, 2020
Objectives The purpose of this paper was to synthesize 4-amino-1,2,4-triazole Schiff base derivative and to evaluate its antitumor activity. Methods 2,4,6-Tris (4-formylphenoxy)-1,3,5-triazine was synthesized by nucleophilic substitution with reaction of
Guo-wei Jiang, Qing Chang, Dong-yu Liang, Yu-ting Zhang, Yong-jun Meng, Qing-qing Yi   +5 more
doaj   +1 more source

An Overview on the Performance of 1,2,3-Triazole Derivatives as Corrosion Inhibitors for Metal Surfaces

International Journal of Molecular Sciences, 2021
This review accounts for the most recent and significant research results from the literature on the design and synthesis of 1,2,3-triazole compounds and their usefulness as molecular well-defined corrosion inhibitors for steels, copper, iron, aluminum ...
Meryem Hrimla, Lahoucine Bahsis, M. R. Laamari, M. Julve, Salah‐E. Stiriba   +4 more
semanticscholar   +1 more source

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

RSC Advances, 2020
The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs.
A. Rani, Gurjaspreet Singh, Akshpreet Singh, Ubair Maqbool, Gurpreet Kaur, Jandeep Singh   +5 more
semanticscholar   +1 more source

Biological importance and synthesis of 1,2,3-triazole derivatives: a review

Green Chemistry Letters and Reviews
1,2,3-triazole is a five-member nitrogen-containing heterocyclic compound with diverse biological activities. A number of 1,2,3-triazole-containing FDA-approved drugs are available on the market, and many other pharmaceutically significant potential ...
Mira Vaishnani, S. Bijani, Mohamed Rahamathulla, Lalji Baldaniya, V. Jain, Kamal Y. Thajudeen, Mohammed Muqtader Ahmed, S. Farhana, Ismail Pasha   +8 more
semanticscholar   +1 more source

Recent Developments Towards the Synthesis of Triazole Derivatives: A Review

Organics
The triazole scaffold is a crucial component of heterocyclic chemistry, serving as a basic building block in organic synthesis, materials science, and medicinal chemistry.
Issam Ameziane El Hassani, Khouloud Rouzi, Anouar Ameziane El Hassani, Khalid Karrouchi, M’hammed Ansar   +4 more
doaj   +1 more source

A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1

Nature Communications
Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis.
J. Rybak, Jinhong Xie, A. Martin-Vicente, X. Guruceaga, Harrison I Thorn, Ashley V. Nywening, Wenbo Ge, A. C. O. Souza, A. Shetty, Carrie McCracken, Vincent M. Bruno, J. Parker, Steve Kelly, Hannah M. Snell, Christina A. Cuomo, P. Rogers, J. Fortwendel   +16 more
semanticscholar   +1 more source