Results 131 to 140 of about 37,042 (298)

Ein portalpräorganisiertes Cucurbit[7]uril‐Ruthenium‐Konjugat ermöglicht motivselektive Proteindetektion

Angewandte Chemie, EarlyView.
Die gezielte Veränderung der Erkennungsumgebung am Portal von Cucurbit[7]uril (CB7) wandelt einen Wirt ohne intrinsisches optisches Signal in einen motivselektiven photolumineszenten Rezeptor um. Das am Portal vororganisierte CB7‐Rubpy‐Konjugat zeigt Änderungen der Zugänglichkeit aromatischer Motive unmittelbar an und ermöglicht dadurch die optische ...
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

Relay Catalysis of Rh (II) and Cobaloxime: Stereoselective Synthesis of Spiroindanones from N‑Sulfonyl-1,2,3-triazoles

, 2018
A novel relay Rh (II)/cobaloxime (III) dual catalysis strategy has been developed for the stereoselective synthesis of indolyl spiroindanones from readily accessible N-sulfonyl-1,2,3-triazoles.
Hongbin Zhai (1457509), Hongbin Zhai, Zhao Liu, Yun Li, Zhao Liu (582169), Qiuchen Du (1789314), Qiuchen Du, Yun Li (692280)   +7 more
core   +1 more source

Triazole-based STING inhibitors

Bioorganic & Medicinal Chemistry
Aberrant activation of the DNA sensing cGAS-STING pathway has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), systemic lupus erythematosus (SLE), and autoinflammatory disorders such as Aicardi-Goutières syndrome (AGS) and STING-associated vasculopathy with onset in infancy (SAVI). Consequently, considerable efforts have been
Singh, Anju, Barasa, Leonard, DeOrsey, Leo, O’Reilly, Maeve D., Choudhary, Shruti, Cahill, Sara E., Rossetti, Thomas, Green, Robert Madison, Humphries, Fiachra, Thompson, Paul R.   +9 more
openaire   +2 more sources

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, EarlyView.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Synthesis, characterization and thermogravimetric study of Cu(II) adducts with 3- and 4-amino-1,2,4-triazole, 2-mercaptothiazoline and 2-mercaptopyridine [PDF]

Journal of the Serbian Chemical Society, 2006
The adducts CuCl2·(3amt), CuCl2·2(3amt)·2H2O, CuCl2·3(3amt), CuCl2·(4amt), CuCl2·2(4amt), CuCl2·3(4amt)·2H2O, CuCl2·(2mct)·H2O, CuCl2·2(2mct)·2.5H2O, CuCl2·3(2mct)·2H2O, CuCl2·(2mcp) and CuCl2·2(2mcp)·H2O, where 3-amino-1,2,4-triazole = 3amt, 4-amino-1,2,
MOAMEN S. REFAT, ROBSON F. DE FARIAS
doaj  

[3 + 2] Cycloaddition of Nitrile Ylides with Diazonium Salts: Copper-Catalyzed One-Pot Synthesis of Fully Substituted 1,2,4-Triazoles

, 2018
A novel [3 + 2] cycloaddition between nitrile ylides and diazonium salts was well-established. This copper-catalyzed three-component reaction was distinguished by mild conditions, ready availability, and operational simplicity, thus opening access to 1,2,
Weiwei Hao (1327251), Pengcheng Lian (5686376), Haiyan Li, Pengcheng Lian, Xueli Wu, Yonggao Zheng, Huihuang Li, Haiyan Li (168109), Yonggao Zheng (5686379), Xiaoguang Bao (1470508), Xiaobing Wan (1490155), Huihuang Li (1701952), Weiwei Hao, Yanwei Zhao (1725145), Yaxiong Wang, Xiaobing Wan, Xueli Wu (3094194), Xiaoguang Bao, Yanwei Zhao, Yaxiong Wang (1701949)   +19 more
core   +1 more source

Harnessing the β‑Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization by Donor/Acceptor Carbenes Derived from 1‑Sulfonyl-1,2,3-triazoles

, 2018
The regioselective and enantioselective intermolecular sp3 C–H functionalization of silicon-substituted alkanes was accomplished using Rh2(S-NTTL)4 with readily available 1-sulfonyl-1,2,3-triazoles as carbene precursors.
Zachary J. Garlets (2734693), Huw M. L. Davies (1336170)   +1 more
core   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Antimicrobial Screening of Some Newly Synthesized Triazoles

, 2017
The study deals with the synthesis and evaluation of some novel triazoles. Amine linked triazoles were prepared through multistep syntheses. 4-Iodobenzoic acid was taken as initial reactant material, which was converted into methyl ester, then to ...
Jeetendra Gupta, Pradeep Mishra, Jeetendra Kumar Gupta   +2 more
core   +1 more source

Synthesis of 1,2,3-triazoles and applications in the synthesis of BODIPY triazoles

, 2020
The 1,2,3-triazole ring is an important heterocycle which has found wide applications due to its interesting properties. Mainly due to the advent of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, 1,2,3-triazoles are nowadays unavoidable in the chemical literature. In the past decade, the development of transition metal-free synthetic
openaire   +2 more sources