Results 111 to 120 of about 38,452 (298)

Selective C(sp²)–H Halogenation of “Click” 4‑Aryl-1,2,3-triazoles

, 2017
Selective bromination reactions of “click compounds” are described. Electron-neutral and electron-deficient arenes selectively undergo unprecedented Pd-catalyzed C–H ortho-halogenations assisted by simple triazoles as modular directing groups, whereas ...
Asier Goitia (3728104), Enrique Gómez-Bengoa (1508548), Arkaitz Correa (1802245)   +2 more
core   +1 more source

Harnessing the β‑Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization by Donor/Acceptor Carbenes Derived from 1‑Sulfonyl-1,2,3-triazoles

, 2018
The regioselective and enantioselective intermolecular sp3 C–H functionalization of silicon-substituted alkanes was accomplished using Rh2(S-NTTL)4 with readily available 1-sulfonyl-1,2,3-triazoles as carbene precursors.
Zachary J. Garlets (2734693), Huw M. L. Davies (1336170)   +1 more
core   +1 more source

Synthesis, bioevaluation and molecular docking study of new piperazine and amide linked dimeric 1,2,3-triazoles

, 2019
In search of more potent new antitubercular agents, a library of novel piperazine tethered dimeric 1,2,3-triazoles were designed by assembling 1,2,3-triazoles and piperazine in a single molecular architectural framework.
Jaiprakash N. Sangshetti (4842510), Tejshri R. Deshmukh (8051162), Vijay M. Khedkar (554344), Vagolu S. Krishna (8051168), Dharmarajan Sriram (816698), Bapurao B. Shingate (8051171), Smita P. Khare (8051165)   +6 more
core   +1 more source

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Synthesis, characterization and thermogravimetric study of Cu(II) adducts with 3- and 4-amino-1,2,4-triazole, 2-mercaptothiazoline and 2-mercaptopyridine [PDF]

Journal of the Serbian Chemical Society, 2006
The adducts CuCl2·(3amt), CuCl2·2(3amt)·2H2O, CuCl2·3(3amt), CuCl2·(4amt), CuCl2·2(4amt), CuCl2·3(4amt)·2H2O, CuCl2·(2mct)·H2O, CuCl2·2(2mct)·2.5H2O, CuCl2·3(2mct)·2H2O, CuCl2·(2mcp) and CuCl2·2(2mcp)·H2O, where 3-amino-1,2,4-triazole = 3amt, 4-amino-1,2,
MOAMEN S. REFAT, ROBSON F. DE FARIAS
doaj  

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles

, 2018
In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature-reported alkynes and azides synthesizable in no more ...
Levré, Doriana, Mercalli, Valentina, Massarotti, Alberto, Alberto Massarotti, Doriana Levré, Chiara Arcisto, Valentina Mercalli (1520014), Alberto Massarotti (1520008), Arcisto, Chiara, Doriana Levré (6013466), Chiara Arcisto (6013469), Valentina Mercalli   +11 more
core   +1 more source

Triazole-based STING inhibitors

Bioorganic & Medicinal Chemistry
Aberrant activation of the DNA sensing cGAS-STING pathway has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), systemic lupus erythematosus (SLE), and autoinflammatory disorders such as Aicardi-Goutières syndrome (AGS) and STING-associated vasculopathy with onset in infancy (SAVI). Consequently, considerable efforts have been
Singh, Anju, Barasa, Leonard, DeOrsey, Leo, O’Reilly, Maeve D., Choudhary, Shruti, Cahill, Sara E., Rossetti, Thomas, Green, Robert Madison, Humphries, Fiachra, Thompson, Paul R.   +9 more
openaire   +2 more sources

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Relay Catalysis of Rh (II) and Cobaloxime: Stereoselective Synthesis of Spiroindanones from N‑Sulfonyl-1,2,3-triazoles

, 2018
A novel relay Rh (II)/cobaloxime (III) dual catalysis strategy has been developed for the stereoselective synthesis of indolyl spiroindanones from readily accessible N-sulfonyl-1,2,3-triazoles.
Hongbin Zhai (1457509), Hongbin Zhai, Zhao Liu, Yun Li, Zhao Liu (582169), Qiuchen Du (1789314), Qiuchen Du, Yun Li (692280)   +7 more
core   +1 more source

Synthesis of 1,2,3-triazoles and applications in the synthesis of BODIPY triazoles

, 2020
The 1,2,3-triazole ring is an important heterocycle which has found wide applications due to its interesting properties. Mainly due to the advent of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, 1,2,3-triazoles are nowadays unavoidable in the chemical literature. In the past decade, the development of transition metal-free synthetic
openaire   +2 more sources