Results 101 to 110 of about 38,452 (298)
, 2018 An unprecedented catalyst-dependent regioselective [3 + 2] cycloaddition of isocyanides with aryl diazonium salts is reported. 1,3-Disubstituted 1,2,4-triazoles were selectively obtained in high yield under Ag(I) catalysis, whereas 1,5-disubstituted 1,2,
Xihe Bi +9 more
core +1 more source
Angewandte Chemie, EarlyView.Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt +9 more
wiley +1 more source
Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases
Tropical Medicine and Infectious DiseaseParasitic diseases represent a severe global burden, with current treatments often limited by toxicity, drug resistance, and suboptimal efficacy in chronic infections.
Jaime A. Isern +3 more
doaj +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 44, 26 October 2026.Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo +7 more
wiley +1 more source
Anticancer properties of 1,2,4-triazole derivatives (literature review)
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta PraktikiCancer is still one of the leading causes of death worldwide. Statistical data show that more than 130,000 people in Ukraine receive this diagnosis as a sentence every year. Cancer can affect any organ and eventually the whole body. In most cases, cancer
I. V. Bushuieva, M. V. Parchenko
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Nature CommunicationsChiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic ...
Ling-Feng Jiang +9 more
doaj +1 more source
The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures
Molecules, 2013 The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures.
Dario Pasini
doaj +1 more source
1,2,3-Triazole N(2)-chelated C–S coupling: Access to ortho methylthiolated 1,2,3-triazoles
, 2019 CuF2-mediated selective C-S coupling of 1,4-disubstituted 1,2,3-triazole halides using the widely available DMSO as the methylthiolation reagent were achieved through the chelation of N(2) atom in triazole ring. The ortho- C-halogen bond in N(1) aryl was
Yubo Jiang (4426555) +5 more
core +1 more source
, 2018 A novel [3 + 2] cycloaddition between nitrile ylides and diazonium salts was well-established. This copper-catalyzed three-component reaction was distinguished by mild conditions, ready availability, and operational simplicity, thus opening access to 1,2,
Weiwei Hao (1327251) +19 more
core +1 more source
Drug, Healthcare and Patient Safety, 2010 Dionissios Neofytos1, Edina Avdic2, Anna-Pelagia Magiorakos31Transplant and Oncology Infectious Disease Program, The Johns Hopkins University School of Medicine, Division of Infectious Diseases, 2Department of Pharmacy, The Johns Hopkins Hospital ...
Dionissios Neofytos +2 more
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