Results 101 to 110 of about 37,042 (298)

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources

Regioselective synthesis and antimicrobial evaluation of some thioether–amide linked 1,4-disubstituted 1,2,3-triazoles

, 2016
A series of 1,4-disubstituted 1,2,3-triazoles having thioether as well as amide linkage were synthesized from aryl(prop-2-yn-1-yl)sulfanes and 2-azido-N-substituted acetamides through Cu(I) catalyzed click reaction.
C. P. Kaushik (748698), Rajesh Thakur (3382991), Pawan Kaur (3382988), Ashima Pahwa (3382985)   +3 more
core   +1 more source

Ligand Control of Copper-Mediated Cycloadditions of Acetylene to Azides: Chemo- and Regio-Selective Formation of Deutero- and Iodo-Substituted 1,2,3-Triazoles

, 2023
The participation of σ-monocopper and σ-bis-copper acetylide in mechanistic pathways for copper-catalyzed cycloaddition (CuAAC) reactions of acetylene with azides was probed by analysis of deuterium distributions in the 1,2,3-triazole product formed by ...
Shanguang Qiu (17707543), Yunlong Wei (4600126), Yanmei Zhao (388081), Luyong Wu (17707546), Dongying Li (3777847)   +4 more
core   +1 more source

Evidence for a Cu(II)‐Catalysed CuAAC Reaction: A Combined Experimental and Computational Study

Angewandte Chemie, EarlyView.
A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Matthew J. Andrews, Thomas M. Richardson, Dean D. Roberts, Aitor Maestro, Timothy A. Hilton, Lia Sotorrios, Carlos Martín‐Fernández, Luca Craciunescu, Frederik Peschke, Aidan P. McKay, Stuart A. Macgregor, Glenn A. Burley, Allan J. B. Watson   +12 more
wiley   +2 more sources

Synthesis and Properties of 6-Aryl-4-azidocinnolines and 6-Aryl-4-(1,2,3-1H-triazol-1-yl)cinnolines

Molecules, 2019
An efficient approach towards the synthesis of 6-aryl-4-azidocinnolines was developed with the aim of exploring the photophysical properties of 6-aryl-4-azidocinnolines and their click reaction products with alkynes, 6-aryl-4-(1,2,3-1H-triazol-1-yl ...
Natalia A. Danilkina, Nina S. Bukhtiiarova, Anastasia I. Govdi, Anna A. Vasileva, Andrey M. Rumyantsev, Artemii A. Volkov, Nikita I. Sharaev, Alexey V. Povolotskiy, Irina A. Boyarskaya, Ilya V. Kornyakov, Polina V. Tokareva, Irina A. Balova   +11 more
doaj   +1 more source

Mechanistic Evidence for Mild Base-Mediated Intermolecular Trans-Aminoacylations of 1‑Acyl-5-amino‑1H‑1,2,4-triazoles and 5‑Amino‑1H‑1,2,4-triazoles to Afford 5‑Acylamino‑1H‑1,2,4-triazoles

Acylation of 5-amino-1H-1,2,4-triazoles is selective for the nitrogen atom at the ring 1-position of the heterocycle to give 1-acyl-5-amino-1H-1,2,4-triazoles.
Nicholas A. Magnus (1950841), Jesús González (1742209), James C. Muir (11139679), Natalie G. Franklin-Charlesworth (18239703)   +3 more
core   +1 more source

Metal-Free Click Synthesis of Functional 1-Substituted-1,2,3-Triazoles

, 2019
The 1,2,3-triazole group is one of the most important connective linkers and functional aromatic heterocycles in modern chemistry. The boom in growth of, in particular, 1,4-disubstituted triazole products since the early 2000’s, can be largely attributed
Marie-Claire Giel (7462496), Tatiana P. Soares da Costa (7462508), John E. Moses (5943762), Jiajia Dong (7462505), Emily R. R. Mackie (7462500), Taijie Guo (7462502), Christopher J. Smedley (5943590)   +6 more
core   +1 more source

AgNO3 as Nitrogen Source for Cu-Catalyzed Cyclization of Oximes with Isocyanates: A Facile Route to N2-Aryl-1,2,3-triazoles

, 2021
A versatile copper-catalyzed [3 + 1 + 1] annulation of oximes and isocyanates with AgNO3 is described. In this conversion, AgNO3 and isocyanates instead of conventional azide or diazonium reagents were used as the nitrogen source.
Yibiao Li (2078623), Xiuwen Chen (4106848), Zhongzhi Zhu (1426822), Lu Chen, Yibiao Li, Yingqi Rao, Tingting Wen, Jingwen Liang (11355657), Junjie Huang, Xiuwen Chen, Junjie Huang (3643540), Lu Chen (75170), Tingting Wen (11355663), Zhongzhi Zhu, Zhichao Chen, Jingwen Liang, Weidong Zhu (316428), Weidong Zhu, Yingqi Rao (11355660), Zhichao Chen (846227)   +19 more
core   +1 more source

Pt‐Mediated Co‐Adsorption of Hydroxyl and Nitrogen‐Heterocyclic Species Over Cu/CuO Heterostructure Enhances Coupled Azotriazole Electrosynthesis and Dual‐Electrode Hydrogen Production

Angewandte Chemie, EarlyView.
Pt@Cu/CuO heterostructures were designed for electrochemical N─N coupling of 3,5‐diamino‐1H‐1,2,4‐triazole. Mechanism investigation revealed that the Pt sites mediated co‐adsorption of substrates and hydroxyl on Cu/CuO sites. The elaborate Pt@Cu/CuO achieved an ultralow working potential of 0.832 VRHE with a high FE of 95%. A long‐term stability of 600
Jiachen Li, Hanggu Su, Yuqiang Ma, Meng Li, Ruhao Zhang, Cihang Wang, Zihang Zhao, Jun Hu, Xiaogang Mu, Xuanjun Wang, Haixia Ma, Zhengxiao Guo   +11 more
wiley   +2 more sources

Novel One-Step Synthesis of Thiazolo[3,2-b]1,2,4-triazoles

, 2016
Reactions of chalcones 3a−f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a−f, which resemble closely some previously prepared COX-2 inhibitors.
Peter J. Steel (1724674), Michael Voronkov (3075576), Alan R. Katritzky (455231), Alfredo Pastor (3049344)   +3 more
core   +1 more source