Results 91 to 100 of about 37,042 (298)
SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA
Angewandte Chemie, EarlyView.SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld +4 more
wiley +2 more sources
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019 The aim of work is the investigation of properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanones and 2((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanols using modern physical-chemical methods.Materials and ...
O. A. Bihdan
doaj +1 more source
Advanced Science, EarlyView.Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.A helical polymer whose chain ends are connected through pillar[5]arene‐based host–guest interactions translates molecular helicity into supramolecular morphology. Solvent‐triggered helicity inversion accompanied by changes in chain rigidity switches the supramolecular architecture between cyclic and rigid‐rod nanostructures.
Tatsuya Nishimura +4 more
wiley +2 more sources
, 2018 An unprecedented catalyst-dependent regioselective [3 + 2] cycloaddition of isocyanides with aryl diazonium salts is reported. 1,3-Disubstituted 1,2,4-triazoles were selectively obtained in high yield under Ag(I) catalysis, whereas 1,5-disubstituted 1,2,
Xihe Bi +9 more
core +1 more source
Advanced Intelligent Discovery, EarlyView.This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo +3 more
wiley +1 more source
A Mesoionic Platform for Persistent Anionic Nitrogen‐Centered Radicals
Angewandte Chemie, EarlyView.Charge did not meet spin: Mesoionic 1,2,3‐triazines undergo reversible one‐electron reduction to persistent anionic nitrogen‐centered radicals. Electron paramagnetic resonance, single‐crystal x‐ray diffraction, and calculations reveal nitrogen‐localized spin and structural reorganization, while crystalline salts show clean redox cycling.
Deepak Ranolia +8 more
wiley +2 more sources
Pd-catalyzed regioselective C-H chlorination of disubstituted 1,2,3-triazoles
, 2018 This paper mainly studied Pd-catalyzed regioselective chlorination of disubstituted 1,2,3-triazoles directed by the 1,2,3-triazole ring. A series of regioselective chlorinated products were synthesized in 47–86% yields using Pd(OAc)2 as a catalyst and ...
Qiong Mo (5262569) +3 more
core +1 more source
, 2020 A copper-catalyzed decarboxylative cycloaddition of propiolic acids, azides, and arylboronic acids is described. The present reaction provides an efficient and convenient method for the synthesis of various fully substituted 1,2,3-triazoles from readily ...
Ya-Min Li +13 more
core +1 more source
Synthesis and Fluorescent Behaviour of 2‑Aryl-4,5-dihydro‑1H‑1,2,4-triazoles
, 2016 A series of new 4,5-dihydro-1H-1,2,4-triazoles was synthesized from amidrazones and acetylenedicarboxylic acid esters in the presence of pyridine in toluene.
Olga O. Nesterenko (3564023) +4 more
core +1 more source