Results 71 to 80 of about 37,042 (298)
An efficient synthesis of novel triazoles incorporating barbituric motifs via [3+2] cycloaddition reaction: An experimental and theoretical study [PDF]
Journal of the Serbian Chemical Society, 2018 In this work, the synthesis of novel triazole derivatives with barbituric motifs in good yields is described. The alkyne was prepared through the Knoevenagel reaction of barbituric derivatives with ortho and para O-propargylated hydroxybenzaldehyde.
Darroudi Mahdieh +2 more
doaj +1 more source
Pharmaceuticals, 2022 Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro +4 more
doaj +1 more source
, 2016 A multicomponent multicatalyst reaction (MC)2R for constructing fully substituted 1,2,3-triazoles is reported. An application of chemoselectivity and latent catalysis in a sequence of multicatalytic reactions confers control over a number of undesired ...
Mark Lautens (1391935) +4 more
core +1 more source
Advanced Science, EarlyView.A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.A programmed assembly strategy based on secondary connectivity integration allows modulating the B←N framework (BNF) microenvironment. Beyond possessing improved stability, the resulting BNFs achieve highly selective adsorption of o‐xylene from all C8 aromatics.
Xiang‐Shuai Li +9 more
wiley +2 more sources
, 2023 An efficient copper-catalyzed three-component tandem reaction of alkynes, α-diazo esters, and TMSN3 to construct triazoles has been developed. Through this strategy, a number of diverse N-substituted 1,2,3-triazoles were conveniently obtained in moderate
Yufen Lv (8823398) +7 more
core +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Directional control within the secondary coordination sphere redefines CO2 reduction by iron porphyrins. Simply rearranging identical urea hydrogen‐bond donors modulates reactivity, revealing that optimal catalysis does not only arise from maximal intermediate stabilization, but also from directional, adaptive non‐covalent interactions that balance ...
Ashutosh Vishwakarma +7 more
wiley +2 more sources
, 2022 A base-mediated (3 + 2) cycloaddition of trifluoroacetohydrazonoyl chlorides with imidates for the construction of 3-trifluoromethyl-1,2,4-triazoles has been described.
Zhen Chen (129176) +3 more
core +1 more source
Advanced Science, EarlyView.Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui +7 more
wiley +1 more source